《淀粉样变性病》PPT课件

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1、AFieldGuidepart2GenomeresourcesSequencesimilarityApr,2007ShandongUniversityGenomeResourcesLocusLinkGenedatabaseUniGeneTraceArchiveMapViewerHomologeneGenomicBiologyGenomeProjects:microbGenomeResourcesLocusLinkGenedatabaseUniGeneTraceArchiveMapViewerHomologeneAsinglequeryinterfaceto…Sequenc

2、es-RefSeqs-GenBank-HomologeneMaps–MapViewerEntrezlinksLocusLinkLocusLinkwillbereplacedbyEntrezGeneonMARCH1,2005.CheckGeneFAQforcurrentinformation.EntrezGeneLocusLinkAsinglequeryinterfaceto…Sequences-RefSeqs-GenBank-HomologeneMaps–MapViewerEntrezlinksEntrezGeneMoreorganisms-allRefSeqgenome

3、sEntrezintegrationGsn[sym]淀粉样变性病GlobalEntrez:NADH2nadh247EntrezGene:NADH226recordsGeneRecordforPongoNADH2HomosapiensDisplayExons/Introns:GeneTableGeneTableARecordWithMoreData:HumanHFE血色沉着病GeneGraphicLinksNM_NP_Introns/Exons:GeneTablelinkstosequenceARecordWithMoreData:HumanHFEEntrezSNPhfe[

4、genename]ANDhuman[orgn]52血色沉着病LinkingtoSNP染色体定位基因定位序列定位SNPinStructureLinktoOMIMVariantsinOMIMGenomeResourcesLocusLinkGenedatabaseTraceArchiveMapViewerHomologeneUniGeneGene-orientedclustersofexpressedsequencesAutomaticclusteringusingMegaBlastEachclusterrepresentsauniquegeneInformedbygenome

5、hitsInformationontissuetypesandmaplocationsUsefulforgenediscoveryandselectionofmappingreagentsUniGeneAClusterofESTsquery5’ESThits3’ESThitsUnigeneUniGeneCollectionsExampleUniGeneClusterHistogramofclustersizesforUniGeneHsbuild177UniGeneClusterHs.95351UniGeneClusterHs.95351UniGeneClusterHs.9

6、5351:expressionUniGeneClusterHs.95351:seqsDownloadsequenceswebpageftpsiteGenomeResourcesLocusLinkGenedatabaseUniGeneTraceArchiveMapViewerHomologeneTheNewHomologeneAutomateddetectionofhomologsamongtheannotatedgenesofcompletelysequencedeukaryoticgenomes.NolongerUniGenebasedProteinsimilariti

7、esfirstGuidedbytaxonomictreeIncludesorthologsandparalogsOrthologs和Paralogs是同源序列的两种类型。Orthologs（垂直同源基因）是指来自于不同物种的由垂直家系（物种形成）进化而来的蛋白，并且典型的保留与原始蛋白有相同的功能。Paralogs（平行同源基因）是那些在一定物种中的来源于基因复制的蛋白，可能会进化出新的与原来有关的功能。请参考文献获得更多的信息。geneduplicationParalogsvsOrthologsearlyglobingene