1、AnatomyoftheHippocampusComputational Models of Neural SystemsLecture 3.2David S. TouretzkySeptember, 2013HumanHippocampus09/25/13Computational Models of Neural Systems2HumanHippocampus09/25/13Computational Models of Neural Systems3HippocampusMeans“Seahorse”Dissected hum
2、an hippocampus next to a specimen of hippocampus leria, one of several dozen species.09/25/13Computational Models of Neural Systems4RatHippocampalFormationseptaltemporalFrom (Amaral & Witter, 1989)09/25/13Computational Models of Neural Systems5Ammon:Egyptiangodwithram's
3、horns09/25/13Computational Models of Neural Systems6RatHippocampalFormationseptaltemporal09/25/13Computational Models of Neural Systems7ComponentsofHippocampalFormation●The“hippocampus”containsCA1-CA3.CA=CornuAmonisAmmon's Horn(Ammon'shorn)●The“hippocampalformation”incl
4、udesCA,dentategyrus(“tooth-likebump”),entorhinalcortex,subiculum,pre-andparasubiculum.●Hilus:reciprocallyconnectedtoDG.09/25/13Computational Models of Neural Systems8EarlyAnatomy:Cajal'sDrawings09/25/13Computational Models of Neural Systems9RatHippocampus09/25/13Computa
5、tional Models of Neural Systems10MonkeyHippocampus09/25/13Computational Models of Neural Systems11HumanHippocampusThe volume of the human hippocampus is about 100 times that of the rat, and 10 times that of the monkey.09/25/13Computational Models of Neural Systems12Basi
6、cCircuitLayer III perforant pathECLayer II perf. pathSchafferMossy fiberscollateralsDGCA3CA1RecurrentThe mossy fiber synapse is one of the collateralslargest and most powerful synapses in the brain.09/25/13Computational Models of Neural Systems13ConnectivityIsMostlyUni-
7、Directional09/25/13Computational Models of Neural Systems14MoreofthePicture●EC:entorhinalcortexOther cortical &EC–LayerIIprojectstoDG/CA3subcortical areas–LayerIIIprojectstoCA1/Subpp–CA1&SubprojectbackDGHilustoEClayerVmf●DG:dentategyrusCA3–mossyfibersprojecttoCASchCA1●C
8、A3–SchaffercollateralstoCA1Sub●Sub:subiculum09/25/13Computational Models of Neural Systems15EvenMorePR: perirh
