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1、ProductSafetyAssessmentPropyleneOxideSelectaTopic:NamesProductOverviewManufactureofProductProductDescriptionProductUsesExposurePotentialHealthInformationEnvironmentalInformationPhysicalHazardInformationRegulatoryInformationAdditionalInformationReferencesNames•CAS
2、No.75-56-9•1,2-propyleneoxide•Methylethyleneoxide•Propyleneoxide(PO)•Propeneepoxide•Methyloxirane•Propeneoxide•1,2-epoxypropane•2-methyloxirane•Alkylepoxide•EpoxypropaneProductOverview•Propyleneoxide(PO)isacolorless,low-boiling,highlyvolatileliquidwithasweetether
3、-like1smell.POishighlyflammableandreactive.Forfurtherdetails,seeProductDescription.•POisachemicalintermediateusedtomakeawiderangeofindustrialandconsumer2products.POisamongthetop50chemicalsproduced(byvolume)intheworld.AboutsixtypercentofthePOproducedannuallybyDowi
4、susedtomanufacturepolyetherpolyols,amajorcomponentofpolyurethanefoam.POisalsousedasarawmaterialinthemanufactureofotherchemicalsthatareusedin:cosmetics,pharmaceuticals,household3detergents,textiles,andmanyothers.Forfurtherdetails,seeProductUses.•SkincontactwithPOi
5、snotlikelytocauseirritationunlessthechemicalistrappedunderclothingorjewelry.EyecontactwithliquidPOmaycausesevereirritationwithcornealinjury,impairedvision,orblindness.VaporinhalationofPOmaycauseupperrespiratoryirritation,4andexcessivevaporinhalationcancauseuncons
6、ciousnessordeath.TheEuropeanUnion(EU)classifiesPOasaCategory2carcinogen(CarcCat2;R45)becauserodentsexposed5toPOfortwoyearsdevelopedbenignandcanceroustumors.Basedonthesamedata,POisclassified“B2–probablehumancarcinogen”bytheUSEnvironmentalProtectionAgency6(EPA).The
7、InternationalAgencyforResearchonCancer(IARC)classifiesPOasapossiblecarcinogen.Forfurtherdetails,seeHealthInformation.•ExposuretoPOcouldoccurataPOproductionfacility,oratafacilityinwhichPOisusedtomanufactureotherproducts.DowmanufacturesPOforindustrialusesonly,makin
8、gdirect7consumerexposuretoPOmanufacturedbyDowunlikely.Forfurtherdetails,seeExposurePotential.•POliquidandvaporareextremelyflammable.Vapormaycauseaflashfireorex
