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1、TheArtandScienceofTotalSynthesisREVIEWSTheArtandScienceofTotalSynthesisattheDawnoftheTwenty-FirstCentury**K.C.Nicolaou,*DionisiosVourloumis,NicolasWinssinger,andPhilS.BaranDedicatedtoProfessorE.J.CoreyforhisoutstandingcontributionstoorganicsynthesisAtthedawnofthetwenty-firstce
2、n-ofthemostexcitingandimportantcoveryandinventionofnewsynthetictury,thestateoftheartandscienceofdiscoveriesofthetwentiethcenturyinstrategiesandtechnologies;andexplo-totalsynthesisisashealthyandvigor-chemistry,biology,andmedicine,andrationsinchemicalbiologythroughousasever.Theb
3、irthofthisexhilarat-continuestofuelthedrugdiscoverymoleculardesignandmechanisticing,multifaceted,andboundlesssci-anddevelopmentprocesswithmyriadstudies.FuturestridesinthefieldareenceismarkedbyWöhler ssynthesisprocessesandcompoundsfornewlikelytobeaidedbyadvancesintheofureain182
4、8.ThismilestoneeventÐbiomedicalbreakthroughsandappli-isolationandcharacterizationofnovelastrivialasitmayseembytoday scations.Inthisreview,wewillchroni-moleculartargetsfromnature,thestandardsÐcontributedtoaªdemysti-clethepast,evaluatethepresent,andavailabilityofnewreagentsandsy
5、n-ficationofnatureºandilluminatedtheprojecttothefutureoftheartandtheticmethods,andinformationandentrancetoapathwhichsubsequentlyscienceoftotalsynthesis.Thegradualautomationtechnologies.Suchadvan-ledtogreatheightsandcountlessrichsharpeningofthistoolisdemonstratedcesaredestinedt
6、obringthepowerofdividendsforhumankind.Beingbothabyconsideringitshistoryalongtheorganicsynthesiscloserto,orevenprecisescienceandafineart,thislinesofpre-WorldWarII,theWood-beyond,theboundariesdefinedbydisciplinehasbeendrivenbythecon-wardandCoreyeras,andthe1990s,nature,which,atpr
7、esent,anddespitestantflowofbeautifulmoleculararchi-andbyaccountingmajoraccomplish-ourmanyadvantages,stilllooksofartecturesfromnatureandservesasthementsalongtheway.Today,naturalaway.enginethatdrivesthemoregeneralproducttotalsynthesisisassociatedfieldoforganicsynthesisforward.wi
8、thprudentandtastefulselectionofKeywords:drugresearch´naturalO
