嗅觉嗅出病理细胞

《嗅觉嗅出病理细胞》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、嗅觉嗅出病理细胞SamZhou2012‐3‐20•Themammalianolfactorysystemdoesmorethanjustdetectfoododorsandpheromones.Thediscoveryofanovelclassofolfactoryreceptorprovidesevidencethatmammalscanalsosniffoutcelldamageanddisease.各种现象例证•Miceuseolfactorycuestoavoidpotentialmate

2、sthatareinfectedwithparasites.•Nematodewormsdevelopaversionstoodorsgivenoffbyharmfulbacteria,therebyavoidingtoxicfood.•Theidentificationofapreviouslyunrecognizedtypeofchemosensoryneuronintherodentnosethatrespondstostimuliassociatedwithcelldamage,disea

3、seandinflammation.•Identifypathogensorassessthehealthstatusofpotentialpartners犁鼻器映射到辅嗅球（accessorybulb）Formyl‐peptide‐evokedCa2+signalsintheintactvomeronasalepithelium.Formylpeptidereceptor在免疫细胞中被发现，用于调节细胞的损伤，疾病和炎症。运用细胞组织工程在细胞膜表面表达FPR（甲酰肽受体）蛋白，通过钙成像分别对

4、物质CRAMP,uPAR,LXA4,fMLF的响应。•犁鼻器感觉神经元有甲酰肽受体，甲酰肽受体也存在于粒细胞，单核细胞，巨噬细胞中，与免疫相关。•甲酰肽受体主要包括：艾滋病毒衍生肽HIV‐derivedpeptide阳离子抗菌肽相关肽cathlithelin‐raltdlatedantiitimicrobioalpeptide(CRAMP)尿激酶型纤溶酶原激活剂受体Urokinase‐typeplasminogenactivatorreceptor(uPAR)血清淀粉样蛋白ASerumamyloi

5、dA(SAA)