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1、Downloadedfromgenome.cshlp.orgonAugust4,2018-PublishedbyColdSpringHarborLaboratoryPressREVIEWMicrofabricationTechnologiesforIntegratedNucleicAcidAnalysisDavidT.Burke,3'4'sMarkA.Burns,2,4andCarlosMastrangelo1DepartmentofHumanGenetics,2DepartmentofChemicalE
2、ngineering,3DepartmentofElectricalEngineeringandComputerScience,and4BioengineeringProgram,UniversityofMichigan,AnnArbor,Michigan48109Inanyfield,thepredictionoffuturetechnologyisaseyetal.1995;McIntyre1996).Althoughanat-riskyventure.Oneneedonlyskimthroughap
3、ileoftempttocovertherangeofpublishedresearchef-popularscientificmagazinesfrom20yearsagotofortshasbeenmade,thisisnotacomprehensiveresurrectalonglistofbeautiful,butunimple-review.mented,technologies,rangingfromhelium-filledskycranestoweedsthatexudehigh-grad
4、emotorTheDemandforNucleicAcidAnalysisisEssentiallyoil.Inthefaceofuncertainty,technologypredic-Unlimitedtionreliesonthreebasicideas.Newtechnologiesare(1)drivenbydemand,(2)incompetitionwithThebiologicalandbiomedicalsciences,fromagri-theeconomicsofestablishe
5、dmethods,and(3)lim-culturetoepidemiologytotaxonomy,haveenthu-itedbytheavailablematerialsandsystemsforde-siasticallyincorporatedDNAandRNAanalysisintosigningandfabricatingtools.theirexperimentaldomains.ExtractionofnucleicInbasicscience,fewareashavewitnessed
6、tech-acid-basedinformationfrombiologicalsampleshasnicalchangesofthemagnitudeobservedrecentlyinbecomeaccessibleworldwide,evenforlaboratoriesDNAandRNAanalysis.Tocontinuethisadvance,withlimitedresourcesandbasictechnicalknowl-futureanalyticaldevicesmustbalanc
7、ecostandac-edge.Ratherthansatisfyingdemand,thisinitialcuracywiththerapidlyincreasingdemandforge-burstofinformationhasstimulatedscientificappe-neticinformation.Thelong-termpotentialofanytitesforanevengreaterbreadthanddepthofdataproposednucleicacidanalysiss
8、ystemwillbelinked(Olson1993).Forexample,ingenetics,variationsintotheefficiencyofitsconstructionmethods.Pho-DNAsequenceprovideanenormousresourcefortolithographicrnicrofabricationisamaturetech-theanalysisofinheritance
