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1、AJCC8thEditionMajorUpdatesinCancerStaging:ImplicationsforOPCtreatment?AHNSTransoralRoboticSurgeryCourseApril,2017KellyMicheleMalloy,MD,FACS•Ihavenoconflictsofinteresttodiscloserelatedtothecontentofthispresentation.AJCCTNMCancerStagingManual,8thEdition•“[We]havebeenproactivetoincorporaten
2、ewrelevantgenomicmarkers,forexample,inbreastcancerandoropharyngealcancer,tobuildandempowerthetraditionalconceptsofstagingofcancer.”–MahulB.Amin,MD,FCAP,Editor•Dr.Aminaddedthetransitiontoincludenewmolecularmarkersisasignificantdevelopmentinthismanual,andhebelievesit“willonlygrowexponentia
3、llyinfuturestagingeffortstoallowstagingtobeverycontemporary,relevantandapplicableinclinicalcareofindividualpatients,”hesaid–AJCCPressRelease,October2016AJCCTNMCancerStagingManual,8thEdition•Originallyintendedtoapplytoallnewcancersin2017,implementationwasdelayeduntilJanuary1,2018.•Allowfo
4、rinfrastructuretobebuilttoaccommodatethechanges.–Thisisnotasnimbleanenvironmentforchange•Bigdata•Electronicmedicalrecords•“Clinicianswillcontinuetousethelatestinformationforpatientcare,includingscientificcontentofthe8thEditionManual.AllnewlydiagnosedcasesthroughDecember31st,2017shouldbes
5、tagedwiththe7thedition.”•“Thetimeextensionwillallowallpartnerstodevelopandupdateprotocolsandguidelinesandforsoftwarevendorstodevelop,test,anddeploytheirproductsintimeforthedatacollectionandimplementationofthe8theditionin2018.”AJCCTNMCancerStagingManual,8thEdition•Whilewewait...KeyUpdates
6、•RestagingPharynxcancersbasedon3subgroups–Nasopharynx(+/-EBV)–HPV(–)OropharynxANDHypopharynx–HPV(+)Oropharynx•EntirelynewstagingparadigmforHPVassociatedOPC•New/UpdatedTstagingfor:–OralCavity–Nasopharynx–CutaneousSCCandBCC•Changeinnomenclature/classificationof“unknownprimary”head&neckcanc
7、er•Expandedstagingfornodaldisease–ENE*CancerStaging:KeyPrinciples•First,youneedalotofexpertswhorepresentallentitiesofcancerstagingandcancerbiology.–28membersoftheAJCCHead&NeckTaskForce•Second,youneeddata.–Pathologicdata(obtainedviasurgery)–Clinicaldata(obtainedonallpatien
