《教学大纲》PPT课件

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1、CharacteristicandmechanismofspecificimmuneresponseChapter13教学大纲掌握免疫耐受的概念、特性熟悉免疫应答的特异性、记忆性的特点熟悉免疫耐受形成的机制了解BCR、TCR多样性及其分子基础、基因重排和多样性的机制了解免疫耐受的形成、维持和终止的生物学意义。specificitymemorytoleranceacquired、rejectdiversity、transferableCharacteristicsofspecificimmuneresponse*SpecificityofIr*Memor

2、yofIr*ToleranceofIrMajorcontentsHaveantigenspecificitySpecificityofimmuneresponseCertainantigenspecificantibodysensitivelymphocyteSpecificbindingMoleculebasisofspecificityDiversityofTCR/BCRMemoryofimmuneresponseconcept：whenantigenfirstenterthebody,theactivatedsignalsandeffectsig

3、nalscankeepinimmunesystem.Therefore,whenthesameantigenreenterthebody,theimmuneresponseagainsttheantigenwillbeprompt,strongerandefficacy。Physicalbasement：Tm，Bm,highaffinityofspecificTCRandBCR,strongerantigenpresentingability,etc.Secondaryimmuneresponseonlymediatedbymemorylymphocy

4、te.TcellmediatedimmunememoryTmiseasiertobeactivatedthannaiveTcell;requirelowerlevelantigenWeakdependenceonco-stimulatorforactivation(CD28/B7)TmsecretemoreCKsthannaiveTcell,highersensitivitytoCKsBcellmediatedimmunememoryBmProducehigheraffinityantibodies;CandevelopAbclassswitch;Ex

5、pressmoremIgG,higherlevelIgA、IgEandMHC-IImolecule，facilitatetotakinginandpresentingofantigen,lowconcentrationofAgcanactivateThandBcellBiologicalsignificanceofTmandBm：hasimportantsignificanceforhostagainstreintroduceofpathogenprovidethetheoreticalbasisforvaccination*Conceptandcha

6、racteristicofimmunetolerance*Induceofimmunetolerance*Formingmechanismofimmunetolerance*SignificanceofstudyingimmunetoleranceToleranceofimmuneresponseAnuniqueformforspecificimmuneresponse*innatetolerance*acquiredtoleranceToleranceofimmuneresponseOwen于1945年发现异卵双胎小牛胎盘血管互相融合，出生后体内均存

7、在两种不同血型的红细胞，即形成红细胞嵌合体（chimeras），并互不排斥。Non-identicaltwinsMedawar胚胎诱导耐受实验(1953年)天然BSAtolerancesolubleBSADresserdemonstrate:Adultmicemaybeinducedimmuneresponse(1962年)EmbryomiceAdultmicetolerance免疫耐受(Immunetolerance)immunetoleranceisastateofunresponsivenessorlowresponsivenessthatiss

8、pecificforaparticularantigenafterhostcontactedt