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1、清华大学遗传学部分Finalrehearsalproblemset.Genetics-Spring2003Therealfinalisabout3timeslong,andisformattedinaslightlydifferentwayforscoringconvenience.1.(5pts)DrosophilaisusedtoinvestigategenesinvolvingtheresistanceofDTT(akindofpesticide*).OneDTTresistancestrainisobtainedaftermultipleroun
2、dsofselection.BycrossingDTTresistancestrainwithsensitivestrain,DTTresistanceof16kindsoffemaleprogeniesisevaluatedandshownabove.Basedontheresults,whatconclusioncanyoudrawfortheseDTTresistancegenes?*insectkillingagent2.(3pts)Afetusdiesinuterus.Severalofitscellsarekaryotyped.About75
3、%ofthecellsaredipoid,and25%tetraploid(have4copiesofeachchromosome).Whatdoyouthinkhappened?Whenindevelopmentdiditprobablyoccur?3.(2pts)Inyeast,ahaploidpetitemutantalsocarriesamutantgenethatrequirestheaminoacidhistidineforgrowth.Thepetite/his-strainiscrossedtoawild-typestrainandtoy
4、ieldthefollowingtetradaftersporulation:2cells:petite/his-2cells:petite/his+Explaintheinheritanceofthepetiteandhis-mutations.4.(2pts)RadiationcangeneratewhatkindofDNAdamage1)deletion2)pointmutation3)translocation4)ALLOFTHEABOVE5.(4pts)Inanisolatedpopulation,anearlyautosomal-recess
5、ive-lethaldiseasehappens1inamillion.Iftheallelefrequencyisstabilized,whatmutationfrequencyforthisdiseasewouldyouexpecttoariseineachgeneration?1)1/millionchromosomes2)2/millionchromosomes3)1/1000chromosomes4)2/1000chromosomes5)Noneoftheabove6.(4pts)HerearetheDNAfingerprintsoffivep
6、eople:achild,mother,andthreepotentialfathers:MotherOffspringMale#1Male#2Male#3Whichmale(s)couldbethefather?（孙路提供）清华生物系2003春季遗传学本科专业试题1.一种双倍体生物染色体44条与另一双倍体生物染色体38条进行交配,杂种通常的染色体数是__________;如果杂种来自双倍体的生殖细胞,则染色体数是__________;以上哪个是可育的__________.(参考答案:41,82,后者)2.判断正误:Hfr与F-系接合时,转移越早的基因转
7、移率越高___________;Hfr与F-系接合时几乎所以细菌都变成Hfr____________;F+与F’不能接合___________;Klinefelter症的患者是男性所以没有体细胞中的巴氏小体___________;由于X染色体的随机失活,杂合的红绿色盲携带者女性多半是色盲的____________;果蝇中性别决定是X染色体与常染色体的比例,所以Y染色体不起性别决定作用_____________.(参考答案:T,F,T,F,F,T)3.如左图,B和C之间发生交换后重组子为________(正常,不正常,有时正常)，D和E之间发生交换后重组子
8、为___________(正常,不正常,有时正常).(参考答案:正常,不正常)4
