Chapter1 Introduction of Molecular Biology

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1、MolecularBiologyByLiLijunReferencesGenesIXbyBenjaminLewinMolecularBiologyoftheCell(4thEditionbyBAlberts)MolecularCellBiology(4thEditionbyHLodish)MolecularBiology(2ndEditionbyRWeaver)分子生物学(InstantNotesinMolecularBiology,2ndEditionbyPTurner）AdvancedMolecularBiology(by

2、RTwyman)现代分子生物学（朱玉贤等）OutlineChapter1IntroductionChapter2StructureofGenomeChapter3DNAReplicationChapter4BiosynthesisofRNAChapter5BiosynthesisofProteinChapter6TheControlofGeneExpressionChapter7ThepolymerasechainreactionChapter8StudygenestructureandgenomesChapter1Introd

3、uction1.DefinitionofMolecularBiology2.HistoryofMolecularBiologyandCentraldogma3.RelationshipbetweenMolecularBiologyandotherdisciplines4.ProspectofMolecularBiology1.1DefinitionofMolecularBiologyTheattempttounderstandthebiologicalphenomenainmolecularterms.Thestudyonthe

4、processofDNAreplication,transcription,translationandexpressionregulationandrelatedproteinsorenzymes.Molecularbiologyisthestudyofgenesandtheiractivitiesatthemolecularlevel,includingtranscription,translation,DNAreplication,recombinationandtranslocation.---RobertWeaverM

5、olecularbiologyseekstoexplaintherelationshipsbetweenthestructureandfunctionofbiologicalmoleculesandhowtheserelationshipscontributetotheoperationandcontrolofbiochemicalprocesses.---Turneretal.Stage1:PreparationStage2:EstablishinganddevelopingofcontemporaryMolecularBio

6、logyStage3:Primaryunderstandingofthenatureoflifeandmodificationoflife-deepdevelopmentstageStage4:Post-genomeera1.2BriefHistoryofMolecularBiologyFromlate1900stoearly1950s•Confirmedthatproteinisoneofthefundamentalmaterialsoflife.•ConfirmedthatDNAisthenatureofgeneticmat

7、erial.Stage1:PreparationBydefinition,theearlyworkongenescannotbeconsideredmolecularbiology,orevenmoleculargenetics,becauseearlygeneticistsdidnotknowthemolecularnatureofgenes.Infact,thechemicalcompositionofgeneswasnotknowuntil1944.Atthatpoint,itbecamepossibletostudyge

8、nesasmolecules,andthedisciplineofmolecularbiologywasborn.Stage2:EstablishinganddevelopingofcontemporaryMolecularBiologyFromearly195