聚碳酸酯型聚氨酯的生物降解性

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1、中国组织工程研究与临床康复74誉劳472010—11—19出版JournalofClinicalRehabilitativeTissueEngineeringResearchNovember19，2010Vo1．14，No．47聚碳酸酯型聚氨酯的生物降解性冰☆庹新林’，夏维娟’，程晓非，吴继功，邹德威Biodegradati0n0fpolyCarbonatepolyurethaneTuoXin-lin’．XiaWei-juan’，ChengXiao-fei。WuJi．gong，ZouDe—weiAbstractBACKGROUND：Differentpolyure

2、thanesvaryinbiostability．Studyonthebiostabilityofpolycarbonatepolyurethane(PCU)is’lnstituteofPolymerScience．Departmentimportanttodeterminethefeasibilityofpolyurethaneusedastheexternalcapsuleofprostheticdiscnucleuspulposus．0fChemicalOBJECTIVE：Toobse~ethe『几vitroand／nvivodegradationprope

3、rtiesofpolyetherpolyurethane(PEU)andPCUwithdifferentEngineering．School0fMaterialsScieRoehardsegmentcontents．andEnginenng．METHODS：The／nv／trohydrolysis，oxidativedegradationandenzymolysisexperimentsofthepolyurethanewereperformedinTsinghuaUniversity。simulatedenvironment．ThepreparedPEUandP

4、CUsamplesweredippedintoPBSand“H202／CoCl2preoxidation—Papain”Beijing100004．systemsforinvitrodegradationstudyat37‘C．andimplantedintothebackmuscleofwhiterabbitsforinvivodegradationChina；‘The306HospitaJ0fChineseexperiment．PLA，BeijingRESUL．TSANDC0NCLUSlON：ThedegradationofPCUisgreatlybe~ert

5、hanPEU，withlargerhardsegmentcontentsand100101Chinastrongerdegradationresistance．PCUismuchmorebiostablethanPEU。it'smoresuitableforlong—timebiologicalimplantation．TuoXin-¨n☆．Doctor,lnstituteofPolymerScience，DepartmentTuoXL，XiaWJ，ChengXF，WuJG．ZouDW．Biodegradationofpolycarbonatepolyuretha

6、ne．ZhongguoZuzhiGongchengYanjiuOfChemicalyuLinchuangKangfu．2010：14(47)：8831—8834．【http：／／wwwcrter．cnhttp：／／en．zglckfcom】Engineering．SchoolOfMaterialsScienoeandEngineering，摘要TsinghuaUniversity,Beijing100084，背景：不同聚氨酯材料的生物稳定性差异巨大，研究聚碳酸酯型聚氨酯的生物稳定性有利于评估其用于人工髓核外囊材料China的可行性。tuoxl@mailtsingh

7、uaeducn目的：观察聚醚型聚氯酯和具有不同硬段含量的聚碳酸酯型聚氨酯材料的体外和体内降解性能。方法：用模拟环境进行聚氨酯的体外水解、氧化降解和酶解实验。分别置于37℃恒温的PBS缓冲液和“H202／COCI2预氧Supportedby：theNationaIHigh-tech化一Papain酶解体系”进行体外降解实验。将聚氨酯植入大耳白兔背部肌肉进行体内降解实验。．Researchand结果与结论：聚碳酸酯型聚氨酯耐降解性远优于聚醚型聚氨酯，且材料硬段含量越大，耐降解性越强。所有研究结果表明DevelopmentPr0gramOfC：hina聚碳酸酯型聚氨酯具

8、有比聚醚型