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时间:2019-05-24
《种磺胺标准品》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、表122种磺胺标准品Table1Thestandardcompoundsof22sulfonamides结构式StructureROR磺胺名称12分子式分子量CASpKaSulfonamidesNSNFormulaMWHOHR1R2NH磺胺胍H57-67-011.3C7H10N4O2S214.24SulfaguanidineHCNH2磺胺HH63-74-110.4C6H8N2O2S172.20SulfanilamideN磺胺嘧啶H68-35-96.5C10H10N4O2S250.28SulfadiazineNCH3磺胺二甲异嘧啶HN515-64-07.4C12H14N4O2
2、S278.33SulfisomidineNCH3磺胺醋酰OH144-80-95.4C8H10N2O3S214.24SulfacetamideHCCH3S磺胺噻唑H72-14-07.2C9H9N3O2S2255.32SulfathiazoleNN磺胺吡啶H144-83-28.4C11H11N3O2S249.29SulfapyridineCH3磺胺甲基嘧啶NH127-79-77.0C11H12N4O2S264.30SulfamerazineNN磺胺对甲氧嘧啶HOCH3651-06-96.7C11H12N4O3S280.30SulfameterNCH3O磺胺二甲噁唑H729-99
3、-77.2C11H13N3O3S267.30SulfamoxoleNCH3CH3N磺胺二甲嘧啶H57-68-17.4C12H14N4O2S278.33SulfamethazineNCH3CH3S磺胺甲噻二唑H144-82-15.5C9H10N4O2S2270.33SulfamethizoleNN磺胺甲氧哒嗪HOCH380-35-36.7C11H12N4O3S280.30SulfamethoxypyridazineNNS琥珀酰磺胺噻唑OOH2H2116-43-8-C13H13N3O5S2355.39SuccinylsulfathiazoleOHCCCCHN磺胺氯哒嗪HCl80
4、-32-05.9C10H9ClN4O2S284.72SulfachloropyridazineNNCH3磺胺甲基异噁唑H723-46-66.0C10H11N3O3S253.28SulfamethoxazoleONN磺胺间甲氧嘧啶NH1220-83-36.5C11H12N4O3S280.30SulfamonomethoxineOCH3N磺胺邻二甲氧嘧啶NH2447-57-65.9C12H14N4O4S310.33SulfadoxineH3COOCH3H3CCH3磺胺二甲异噁唑H127-69-55.0C11H13N3O3S267.30SulfisoxazoleNOOCH3N磺胺
5、间二甲氧嘧啶HN122-11-26.3C12H14N4O4S310.33SulfadimethoxineOCH3磺胺喹噁啉NH59-40-55.5C14H12N4O2S300.34SulfaquinoxalineN磺胺硝苯ONO2122-16-714.5C14H13N3O5S335.34SulfanitranH3CCH2.2色谱条件WatersACQUITYUPLCBEHC18柱(1.7µm,2.1mm×50mm);流动相:甲醇(A)和0.1%甲酸水溶液(B),梯度洗脱程序:0~2.6min,5%A~16%A;2.6~3.8min,16%A~22%A;3.8~4.8min,
6、22%A~25%A;4.8~6.6min,25%A;6.6~7.0min,25%A~55%A;7.0~9.2min,55%A~95%A;9.2~10.0min,95%A,10.0~11.0min,95%A~8%A;流速0.2mL/min;柱温30℃;样品室温度20℃;进样量5µL。2.3质谱条件电喷雾离子源;正离子扫描;毛细管电压3.5kV;射频透镜电压0.0V;离子源温度120℃;去溶剂气温度350℃;去溶剂气流量500L/h;锥孔气流量50L/h;光电倍增器电压650V;碰撞气体为氩气,碰撞-3气压3.2×10mbar;多反应监测(MRM)模式检测,22种磺胺的质谱分析
7、参数见表2。表222种磺胺的质谱分析参数Table2MSparametersfor22sulfonamidesanalysis保留时间监测离子对锥孔电压碰撞能量磺胺名称RetentiontimeMonitoringionpairsConeCollisionSulfonamides(min)(m/z)voltage(V)Energy(eV)磺胺胍215.8/108.622230.89Sulfaguanidine215.8/156.92215磺胺173.2/91.415180.99Sulfanilamide173.2/
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