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1、CurrentMedicinalChemistry,2007,14,827-845827SARandQSARoftheAntioxidantActivityofFlavonoids*,11112DraganAmi#,Du"ankaDavidovi#-Ami#,DragoBe"lo,VesnaRastija,BonoLu$i#and*,2NenadTrinajsti#1FacultyofAgriculture,TheJosipJurajStrossmayerUniversity,P.O.Box719,HR-31107Os
2、ijek,Croatia2TheRugjerBo"kovi#Institute,P.O.Box180,HR-10002Zagreb,CroatiaAbstract:Flavonoidsareagroupofnaturallyoccurringphytochemicalsabundantlypresentinfruits,vegetables,andbev-eragessuchaswineandtea.Inthepasttwodecades,flavonoidshavegainedenormousinterestbeca
3、useoftheirbeneficialhealtheffectssuchasanti-inflammatory,cardio-protectiveandanticanceractivities.Thesefindingshavecontributedtothedramaticincreaseintheconsumptionanduseofdietarysupplementscontaininghighconcentrationsofplantflavon-oids.Thepharmacologicaleffectof
4、flavonoidsismainlyduetotheirantioxidantactivityandtheirinhibitionofcertainen-zymes.Inspiteofabundantdata,structuralrequirementsandmechanismsunderlyingtheseeffectshavenotbeenfullyun-derstood.Thisreviewpresentsthecurrentknowledgeaboutstructure-activityrelationship
5、s(SARs)andquantitativestruc-ture-activityrelationships(QSARs)oftheantioxidantactivityofflavonoids.SARandQSARcanprovideusefultoolsforrevealingthenatureofflavonoidantioxidantaction.Theymayalsohelpinthedesignofnewandefficientflavonoids,whichcouldbeusedaspotentialth
6、erapeuticagents.Keywords:SAR,QSAR,flavonoids,antioxidantactivity,freeradicalscavenging,metalchelation,enzymeinhibition,prooxi-dantactivity,mechanisms,modelling,moleculardescriptors.INTRODUCTIONandmorewatersoluble,permittingitsstorageinthecellvacuole.Structuraldi
7、versityineachflavonoidfamilyarisesFlavonoidsareagroupofnaturallyoccurringpolypheno-fromthevarioushydroxylation,methoxylation,andglycosy-liccompoundsubiquitouslyfoundintheplantkingdom[1,lationpatternsofringsubstitution.2].Theyarewidespreadinvegetables,fruits,flow
8、ers,seeds,andgrains[3].TheexactroleofthesesecondarymetabolitesHealthEffectsofFlavonoidsisstillunclear,butitisknownthatflavonoidsareimportantResearchinthefieldofflavon
