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1、Pharmacology,BiochemistryandBehavior98(2011)511–517ContentslistsavailableatScienceDirectPharmacology,BiochemistryandBehaviorjournalhomepage:www.elsevier.com/locate/pharmbiochembehMemoryfacilitatingeffectsofagomelatineinthenovelobjectrecognitionmemorypa
2、radigmintherataa,⁎,ElisabethMocaërbbValérieBertaina-Anglade,ChristopheDrieu-La-Rochelle,LaureSeguinaBiotrial,DepartmentofPreclinicalPharmacology,7-9rueJ-LBertrand,35000Rennes,FrancebInstitutdeRecherchesInternationalesServier,6placedesPléiades,92415Cour
3、bevoie,FrancearticleinfoabstractArticlehistory:Theaimofthepresentstudywastoevaluatetheeffectsofagomelatine,anantidepressantwithmelatonergicReceived27September2010agonistand5-HT2Cantagonistproperties,intheratnovelobjectrecognition(NOR)task,amodelofshort
4、-Receivedinrevisedform4February2011termepisodicmemory.Toassessthepotentialinvolvementofitschronobioticactivity,singleintraperitonealAccepted14February2011administrationofagomelatineandNORtestingwereperformedeitherintheeveningorinthemorning.InAvailableo
5、nlinexxxxbothconditions,usinga24hretentioninterval,vehicle-treatedratsdidnotdiscriminatebetweenthenovelandthefamiliarobject(recognitionindexwasnotdifferentfromchanceperformance)whileobjectmemoryKeywords:Agomelatineperformanceofratstreatedwithagomelatin
6、eeitherintheevening(10and40mg/kg)orinthemorning(2.5,Memoryfacilitatingeffects10,and40mg/kg)wassignificantlyimproved.Moreover,theselective5-HT2CantagonistSB242,084(0.63,Novelobjectrecognitiontask2.5,and10mg/kg)andmelatonin(2.5,10,and40mg/kg)displayedalso
7、memoryfacilitatingeffectsinbothMelatoninadministrationconditions.Finally,thioperamideusedaspositivereferencecompoundtovalidatetheSB242,084experimentalconditions,demonstratedamemoryfacilitatingeffect.Inconclusion,agomelatinewasshowntoRatpossessmemoryfac
8、ilitatingeffectsintheratNORtaskandbothmelatonergicagonistand5-HT2Cantagonistpropertiescouldbeinvolvedintheseeffects.©2011ElsevierInc.Allrightsreserved.1.Introductionbetweenplasmaagomelatineconcentrationandentrainmenthasbeendemonstrated(