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1、--------------------------------Insightsintohominidevolutionfromthegorillagenomesequence从大猩猩的基因组序列深入了解人类进化----------------------------------------------------------AylwynScally1,JulienY.Dutheil2{,LaDeanaW.Hillier3,GregoryE.Jordan4,IanGoodhead1{,JavierHerrero4,AsgerHobolth2,TuuliLappalainen5,Thomas
2、Mailund2,TomasMarques-Bonet3,6,7,ShaneMcCarthy1,StephenH.Montgomery8,PetraC.Schwalie4,Y.AmyTang1,MichelleC.Ward9,10,YaliXue1,BryndisYngvadottir1{,CanAlkan3,11,LarsN.Andersen2,QasimAyub1,EdwardV.Ball12,KathrynBeal4,BrendaJ.Bradley8,13,YuanChen1,ChrisM.Clee1,StephenFitzgerald4,TinaA.Graves14,YongGu1
3、,PaulHeath1,AndreasHeger15,EmreKarakoc3,AnjaKolb-Kokocinski1,GavinK.Laird1,GertonLunter16,StephenMeader15,MatthewMort12,JamesC.Mullikin17,KasperMunch2,TimothyD.O’Connor8,AndrewD.Phillips12,JavierPrado-Martinez6,AnthonyS.Rogers1{,SabaSajjadian3,DominicSchmidt9,10,KatyShaw12,JaredT.Simpson1,PeterD.S
4、tenson12,DanielJ.Turner1{,LindaVigilant18,AlbertJ.Vilella4,WeldonWhitener1,BaoliZhu19{,DavidN.Cooper12,PieterdeJong19,EmmanouilT.Dermitzakis5,EvanE.Eichler3,11,PaulFlicek4,NickGoldman4,NicholasI.Mundy8,ZeminNing1,DuncanT.Odom1,9,10,ChrisP.Ponting15,MichaelA.Quail1,OliverA.Ryder20,StephenM.Searle1,
5、WesleyC.Warren14,RichardK.Wilson14,MikkelH.Schierup2,JaneRogers1{,ChrisTyler-Smith1&RichardDurbin1人名------------------------------------------------------------------------------Gorillasarehumans’closestlivingrelativesafterchimpanzees,andareofcomparableimportanceforthestudyofhumanoriginsandevoluti
6、on.Herewepresenttheassemblyandanalysisofagenomesequenceforthewesternlowlandgorilla,andcomparethewholegenomesofallextantgreatapegenera.Weproposeasynthesisofgeneticandfossilevidenceconsistentwithplacingthehuman–chimpanzeeandhuman–chimpanzee–gorillaspeciationeventsatapproximately6and10millionyearsago
7、.In30%ofthegenome,gorillaisclosertohumanorchimpanzeethanthelatteraretoeachother;thisisrareraroundcodinggenes,indicatingpervasiveselectionthroughoutgreatapeevolution,andhasfunctionalconsequencesingeneexpression.Ac
