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1、ExecutiveSummary*JackHirsh,GordonGuyatt,GregoryW.Albers,RobertHarringtonandHolgerJ.SchünemannChest2008;133;71S-109SDOI10.1378/chest.08-0693Theonlineversionofthisarticle,alongwithupdatedinformationandservicescanbefoundonlineontheWorldWideWebat:http://www.che
2、stjournal.org/content/133/6_suppl/71S.full.htmlCHESTistheofficialjournaloftheAmericanCollegeofChestPhysicians.Ithasbeenpublishedmonthlysince1935.Copyright2008bytheAmericanCollegeofChestPhysicians,3300DundeeRoad,Northbrook,IL60062.Allrightsreserved.Nopartoft
3、hisarticleorPDFmaybereproducedordistributedwithoutthepriorwrittenpermissionofthecopyrightholder.(http://www.chestjournal.org/site/misc/reprints.xhtml)ISSN:0012-3692Downloadedfromwww.chestjournal.orgbyguestonSeptember5,2009Copyright©2008AmericanCollegeofChes
4、tPhysiciansCHESTSupplementANTITHROMBOTICANDTHROMBOLYTICTHERAPY8THED:ACCPGUIDELINESExecutiveSummary*AmericanCollegeofChestPhysiciansEvidence-BasedClinicalPracticeGuidelines(8thEdition)JackHirsh,MD,FCCP,Chair;GordonGuyatt,MD,FCCP;GregoryW.Albers,MD;RobertHarr
5、ington,MD,FCCP;andHolgerJ.Schu¨nemann,MD,PhD,FCCP(CHEST2008;133:71S–105S)criticalreviewoftheliteraturerelatedtomanage-mentofthromboembolicdisorders.Keywords:guidelines;recommendationsIneachchapter,theclinicalquestionunderconsid-eration,theclinicaltrialseval
6、uatingtheevidence,andAbbreviations:ACCPAmericanCollegeofChestPhysicians;therecommendationsarelinkedbyanumberingACSacutecorronarysyndromes;AFatrialfibrillation;AISarterialischemicstroke;APTTactivatedpartialthrom-schemecommontothesethreeitems.Therecommen
7、-boplastintime;CABGcoronaryarterybypassgrafting;dationsareincludedatthebeginningofthechaptersCrClcreatinineclearance;CSVTcerebralsinovenousandarepresentedinthisexecutivesummary.thrombosis;CTPHchronicthromboembolicpulmonaryhy-pertension;CVLcentralvenous
8、line;DVTdeepveinthrom-Thegradingsysteminthe8theditionoftheACCPbosis;GCSgraduatedcompressionstockings;GPglyco-guidelinesreflectsthesystemadoptedforallACCPprotein;HITheparin-inducedthrombocytopenia;I