盐酸羟考酮控释片治疗晚期癌症疼痛的临床应用

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1、万方数据·6·生国鉴瘟医堂盈麦鱼i!!丝＆!婴堂丛旦也丛笪丝塑!Q塑：!』t(12盐酸羟考酮控释片治疗晚期癌症疼痛的临床应用陈樟树王文武欧阳学农陈曦房文铮李捷(南京军区福州总医院肿瘤科，福州350025)摘要目的：观察盐酸羟考酮控释片(奥施康定)治疗晚期癌症中、重度疼痛的临床效果、不良反应及患者生活质量的改善情况。方法：68例中、重度疼痛患者给予奥施康定镇痛治疗，初始剂量10ms／12h，正在用吗啡类镇痛药者，按照吗啡1／2剂量换算。根据疼痛情况调整剂量，直至患者无痛或基本无痛，每位患者至少治疗15d以上，同时进行疼痛强度、生活质量评

2、分及不良反应观察。结果：奥施康定的最终滴定剂量为：≤30mg／d的30例(44．1％)，31—60mg／d的16例(23．5％)，6l～120mg／d的18例(26．5％)，≥120mg／d的4例(5．9％)。总疼痛缓解率为95．6％，其中完全缓解27例(39．7％)，明显缓解33例(48．5％)，中度缓解5例(7．4％)。患者生活质量明显提高，不良反应少且轻微。结论：盐酸羟考酮控释片治疗中、重度癌性疼痛疗效显著，不良反应较少，能显著改善癌症患者的生活质量。关键词癌症；疼痛；盐酸羟考酮控释片；治疗CLINICALAPPLICATION

3、OFOXYCODONEHYDRoCHLORIDECONTROLLEDJRE-LEASETABLETSINTHETREATMENTOFTERMINALCANCERPAINCHENZhang—Shu，WANGWen-Wu，OUYANGXue—Nong，CHENXi，FANGWen—Zheng，LIJie(DepartmentofoneoeogyNanJingMilitaryCommandFuZhouGeneralHospital，FuZhou，350025，China)AbstractObjective：Toevaluatetheeffi

4、cacyandsidee艉ctsofoxycodonehydrochloridecontrolled-·re·—leasetabletsinthetreatmentofmoderatetoseverepaininpatientswithterminalcancerandtoobserveanyimprovementonthecancerpatientsqualityoflife．Methods：Sixty·eightpatientswithmoderateorse—verecancerpainweretreatedwithoxycod

5、onehydrochloridecontrolledreleasetablets．Theinitialdosewas10mr／12h，orI／2thatofthestandardmorphineregimen．Duringthecourseoftreatment，thedosagewasadjustedaccordingtothepatientsdesiresuntilthepaincompletelyornearlydisappeared．Eachpatientreceivedthetreatmentforatleast15days

6、．Atthesametime，adversee镌cts，qualityoflifeandscoresfortheintensityofpainwereobservedandrecorded．Results：ThefinaltitrateddosageofoxyeodoneWasde—scribedasbelow：30cases(44．1％)receivedadosageof≤30mg／d，16cases(23．5％)receivedadosageof31to60mg／d，18cases(26．5％)receivedadosageof6

7、1to120mg／dandthosein4cases(5．9％)receivedadosageofmorethan120mg／d．TheoverallreliefratefrompainWas95．6％，andtheratesofexcellent，effectiveandmoderatereliefWas39．7％，48．5％and7．4％，respectively．Mildsideeffectsandimprovedqualityoflifewereobservedafteroxycodonetreatment．Conclusio

8、ns：Oxycodoneiseffectiveintreatmentofmoderateandseverecancerpain．Thesidee仃ectsofoxycodonearemild，andthedrugcans