运动相关脑磁波之脑部信号源动态造运动相关脑磁波之脑部信号源动态造

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1、運動相關腦磁波之腦部信號源動態造運動相關腦磁波之腦部信號源動態造影影ImagingCorticalSourceImagingCorticalSourceDynamicsofMovementDynamicsofMovement--RelatedRelatedNeuromagneticFieldNeuromagneticField計畫編號：NSC92-2218-E-010-005執行期限：92年8月1日至93年7月31日主持人：陳麗芬助理研究員國立陽明大學神經科學研究中心特約助理研究員臺北榮民總醫院教學研究部共同主持人：陳永昇助理教授國立交通大學資訊工

2、程學系謝仁俊主治醫師臺北榮民總醫院教學研究部教授暨所長國立陽明大學衛生資訊與決策研究所計畫參與人員：劉宏毅、李宗展、黃勁霖、鄭志瑜研究生國立交通大學資訊工程學系MEG(MEG(MagnetoEncephaloGraphyMagnetoEncephaloGraphy))Vectorview:306channelsmanufacturedbyElektaInc.installedinTaipeiVeteransGeneralHospitalMEGSourceModelingMEGSourceModelingòForwardproblem:òInput:

3、thepositions,theamplitudeandtheorientationsofthesourcecurrentdipolesòOutput:toestimatethemeasureddatafromMEGsensorsòInverseproblem:òInput:asetofmeasureddataòOutput:toestimatetheparametersrepresentingthesourcecurrentdipoles,includingpositions,theamplitudeandtheorientationsForwa

4、rdModelForwardModel±Sourcemodel±Equivalentcurrentdipole(ECD)±Parameters:location,amplitude,andorientation±Fix,rotating,movingdipoles±Headmodel±relatedtothecomputationofvolumecurrent±Sphericalmodel±Boundaryelementmodel(BEM)±Finiteelementmodel(FEM)SourceModelSourceModelMaxwellMa

5、xwell‘‘sequationssequations：：E∇⋅=ρε0E∇×=−∂B∂tB∇⋅=0BJ∇×=()+∂Eµ0ε0∂tE:electricfieldε0:dielectricconstantB:magneticfieldµ:permeability0J:currentdensityρ:chargedensitySourceModel(cont.)SourceModel(cont.)òHeadisaconductorconsistingofHeadisaconductorconsistingofdifferentdifferenttis

6、suestissues..òUsingGreenUsingGreen’’stheorywithboundarystheorywithboundaryconditionwecanobtainthemagneticfieldconditionwecanobtainthemagneticfieldm()()µ0()−+⎛()()3⎞Br=B∞r−∑σi−σi⎜∫Vrnir'×dd⎟dr'4πi=1⎝Si⎠()µ0∫p()3Br=r'×dddr'∞J4πGn(r):outwarddirectedunitnormalvectori+:conductivity

7、outsidethesurface-:conductivityinsidethesurfaced:r-rqHeadModelHeadModelòBoundaryBoundary--elementelement--methodmodel(BEM)methodmodel(BEM)òSphericalheadmodelSphericalheadmodelrr:sensorposition:sensorpositionrrq:positionofdipole:positionofdipoleqq:momentofdipole:momentofdipoleH

8、eadModel(cont.)HeadModel(cont.)òBecausetheBecausetheradialmag