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ID:37509898
大小:34.00 KB
页数:9页
时间:2019-05-24
《绝经前后妇女性激素六项与骨质疏松的关系》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、绝经前后妇女性激素六项与骨质疏松的关系【关键词】绝经;妇女;性激素;骨质疏松摘要:目的探讨绝经前后妇女性激素6项与骨质疏松的关系,为指导骨质疏松患者的性激素替代治疗提供科学的依据。方法88例妇女分成绝经前期(1组)、围绝经期(2组)和绝经后期(3组)三组,分别抽血测定性激素6项:雌二醇(E2)、催乳素(PRL)、促卵泡成熟素(FSH)、促黄体生成素(LH)、孕酮(P)、睾酮(T),并于当月测量右跟骨定量超声。结果1组E2:(98.32±11.64)Pg/ml、T:(0.39±0.03)ng/ml、BUA:(66.3±4.6)dB/MHz、S
2、OS:(1527±26)m/s、SI:(91±10)%。2组E2:(47.27±6.62)Pg/ml、T:(0.25±0.02)ng/ml、BUA:(64.7±3.8)dB/MHz、SOS:(1499±28)m/s、SI:(82±13)%,与1组比较除BUA外差异均有显著性意义(P<0.01)。3组E2:(9.46±1.4)Pg/ml、T:(0.12±0.01)ng/ml、BUA:(54.2±5.1)dB/MHz、SOS:(1470±47)m/s、SI:(60±12)%,与2组比较差异均有显著性意义(P<0.01)。结论妇女绝经后骨质疏松症
3、的发生、发展与血性激素6项中E2及T的进行性下降有密切的关系,治疗上宜采用补充雌激素为主结合补充孕激素和雄激素的性激素替代疗法。关键词:绝经;妇女;性激素;骨质疏松Therelationshipbetweenosteoporosisandthelevelofsexhormonesinmenopausewomen.SURu-kun,LIFo-bao,LIUXing-mo,etal.(GuangzhouMunicipalSixthPeople'sHospital,Guangzhou510655,Guangdong,P.R.China)Abstr
4、act:ObjectiveToinvestigatetherelationshipbetweenosteoporosisandsexhormoneofmenopausalwomen.Methods88womensweredividedinto3groups,Group1consistedofpremenopausalwomen,Group2consistedofperi-menopausalwomenandGroup3consistedofpostmenopausalwomen.ThelevelsofEstradiol(E2),Prolac
5、tin(PRL),ProlanB(PB),luteinizinghor-mone(LH),Pro-gesterone(P),andTestosterone(T)weretested.Broadbandultrasoundattenuation(dB/MHz),speedofsound(m/s),andstiffnessindex(%)weremeasuredattherightcalcaneaofthewomen.ResultsThelevelofE2,T,BUA,SOSandSIwere98.32±11.64,0.39±0.03,66.3
6、±4.6,1527±26and91±10,showingsignificantdifferenceascomparedwiththatofGroup2exceptthelevelofBUA(E2:47.27±6.62,T:0.25±0.02,BUA:64.7±3.8,SOS:1499±28,SI:82±13)(P<0.01);ThelevelofE2,T,BUA,SOSandSIwere:9.46±1.4,0.12±0.01,:54.2±5.1,1470±47,60±12,showingsignificantdif-ferenceascom
7、paredwiththatofGroup2(P<0.01).ConclusionTheoccurrenceofosteoporosisinmenopausalwomenisasso-ciatedwiththeprogressivereductionofsexhormoneE2andT.SupplementofE2,combinedwithPandT,couldbeusedfortreat-mentofosteoporosisinmenopausalwomen.Keywords:Menopause;Women;Sexhormone;Osteo
8、porosis骨质疏松症是以低骨量和骨的微结构破坏为特征,导致骨强度降低,骨脆性增加,容易发生骨折的一种全身性代谢性骨病。骨质疏松症病因复杂,目前认为性激素对骨代谢的调控在骨质疏
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