《雌激素代治疗》PPT课件

《《雌激素代治疗》PPT课件》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、EstrogenReplacementTherapyandthePreventionofCoronaryHeartDiseaseinWomen:FriendorFoe?DavidParra,Pharm.D.,BCPSClinicalPharmacySpecialistDepartmentofCardiologyVeteransAffairsMedicalCenterWestPalmBeach,FLObjectivesUnderstandthemagnitudeofcoronaryheartdisease(CHD)inpostmenopausalwomenExplainthemecha

2、nismsbehindestrogen’sproposedcardioprotectiveeffectReviewtheobservationaldatasupportingtheuseofestrogeninpreventingCHDDiscusstheresultsoftherecentlycompletedHeartandEstrogen/progestinReplacementStudy(HERS)andapplythemtoclinicalpracticeCardiovascularDiseaseinWomenOneintwowomenwilldieofcardiovasc

3、ulardisease(CVD)ifallformsofmajorCVDwereeliminatedlifeexpectancywouldincreaseby10yearsOnein26womenwilldieofbreastcancerifallformsofcancerwereeliminatedlifeexpectancywouldincreaseby3years1998HeartandStrokeStatisticalUpdate,AHA.63%ofwomen(48%ofmen)diesuddenlyfromcoronaryheartdisease44%ofwomen(27%

4、ofmen)willdiewithinoneyearafteraheartattackCardiovascularDiseaseinWomen1998HeartandStrokeStatisticalUpdate,AHA.505,44033,130256,84448,96145,1360100200300400500600TotalCVCancerCOPDPneumoniaFluDiabetesDeathsinthousandsLeadingCausesofDeathforAllFemalesUnitedStates1995MortalityDataAdaptedfrom1998He

5、artandStrokeStatisticalUpdate,AHA.50%CoronaryHeartDisease1%CongenitalHeartDefects1%RheumaticFever/RheumaticHeartDisease4%CongestiveHeartFailure2%Atherosclerosis4%HighBloodPressure22%OtherCoronaryHeartDisease:DespiteAdvances,Stillthe#1KillerPercentageBreakdownofDeathsFromCardiovascularDiseases

6、UnitedStates:1995Mortality,FinalData16%StrokeAmericanHeartAssociation1998HeartandStrokeFacts:StatisticalUpdate4204404604805005207980818283848586878889909192939495YearsDeathsinThousandsMalesFemalesCardiovascularDiseaseMortalityTrendsUnitedStates1995MortalityDataAdaptedfrom1998HeartandStrokeStati

7、sticalUpdate,AHA.PremenopausalPostmenopausalDecreaseinHDLIncreaseinLDL,triglycerides,apolipoproteinsBandA-IIncreaseindiastolicbloodpressureMenopauseexertsanegativeeffectonCHDriskIncidenceofCoronaryHeartDisease0246810121416Annualra