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1、NUTRITIONANDCANCER,57(1),2837CopyrightC2007,LawrenceErlbaumAssociates,Inc.Zapotin,aPhytochemicalPresentinaMexicanFruit,PreventsColonCarcinogenesisGenovevaMurillo,WendyH.Hirschelman,AikoIto,RobertM.Moriarty,A.DouglasKinghorn,JohnM.Pezzuto,andRajendraG.MehtaAbstract:Zapotin(5,6,2,6
2、-tetramethoxyflavone),foundinIntroductionthetropicalfruitzapoteblanco(Casimiroaedulis),iscon-sumedinmanypartsoftheworld,includingCentralAmericaColoncancercontinuestobeamajorcauseofmortalityandAsia.Previously,wehavedemonstratedinvitrochemo-intheUnitedStates;itisestimatedthat112,340p
3、eoplewillpreventiveactivityofextractsderivedfromtheseedsofC.bediagnosedwithcoloncancerand52,180deathswillbeedulis.Inthepresentstudy,weexaminedtheeffectsofnaturalattributedtothisdiseasein2007(1).GiventhesubstantialandsyntheticzapotininSW480,SW620,andHT-29colonmorbidityandmortalityas
4、sociatedwithcolorectalmalig-cancercelllinesandonthegenerationofaberrantcryptnancies,cancerpreventionhasemergedasaveryattractivefoci(ACF)usingmice.Zapotintreatment(IC50=2.74×approachtocombatthisdisease.Thefieldofcancerchemo-10−7M)resultedinamarkedsuppressionofcellprolifer-prevention,
5、whichreferstotheadministrationofnaturalorationintheHT-29cells.Cellcycleanalysisdemonstratedsyntheticcompoundstoblock,reverse,delay,orpreventtheasignificantaccumulationofcellsintheG2-Mphase,withdevelopmentofinvasiveneoplasms,hasprovidedevidencetoaconcomitantdecreaseofcellsintheG0-G1p
6、hase,aftersupporttheconceptthatanumberofmicronutrientsfoundintreatmentwithzapotin(molecularweight=342.35g/mol;thediet(forexample,calcium,selenium,andvitaminD)of-1µMfor18,24,and48h).Zapotintreatmentenhancedferprotectionagainstcoloncancer(25).Additionally,dataapoptosisinallofthecolon
7、cancercelllinesstudied.Forthefromepidemiologicalandexperimentalstudieshaveestab-studyofACF,5-wk-oldCF-1miceweregivensubcutaneouslishedtheanticancerpropertiesofseveralnon-nutritivecom-injectionsofazoxymethane(AOM;10mg/kgbodyweight,ponentsinfoods(6,7).Moreover,severalofthesefood-base
8、dBW)weeklyfor2wk,andzapoti
