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1、2September2012SciFinderScholarPage:1SubstanceIdentifiertaskstartedonSunSep2,2012at1:00PMExploredbySubstanceIdentifierinREGISTRY.REGISTRYAnswers1for71486-22-1ExploredReactionscontainingRegistryNumber71486-22-1asaproductinCASREACT24Reactions.Copyrights:C
2、APLUS:Copyright?2009AmericanChemicalSociety.AllRightsReserved.(TheUKpatentmaterialinthisproduct/serviceisUKCrowncopyrightandismadeavailablewithpermission.?CrownCopyright.TheFrench(FR)patentmaterialinthisproduct/serviceismadeavailablefromInstitutNationa
3、ldelaProprieteIndustrielle(INPI).)MEDLINE:ProducedbytheU.S.NationalLibraryofMedicineREGISTRY:Copyright?2009AmericanChemicalSociety.AllRightsReserved.(SomerecordscontaininformationfromGenBank(R).Seealso:BensonD.A.,Karsch-MizrachiI.,LipmanD.J.,OstellJ.,R
4、appB.A.,WheelerD.L.Genbank.Nucl.AcidsRes.28(1):15-18(2000).PropertyvaluestaggedwithICarefromtheZIC/VINITIdatafileprovidedbyInfoChem.)CASRegistryisaservicemarkoftheAmericanChemicalSociety.CASREACT:Copyright?2009AmericanChemicalSociety.AllRightsReserved.
5、CASREACTcontainsreactionsfromCASandfrom:ZIC/VINITIdatabase(1974-1999)providedbyInfoChem;INPIdatapriorto1986;BiotransformationsdatabasecompiledunderthedirectionofProfessorDr.KlausKieslich;organicreactions,portionscopyright1996-2006JohnWiley&Sons,Ltd.,Jo
6、hnWileyandSons,Inc.,OrganicReactionsInc.,andOrganicSynthesesInc.Reproducedunderlicense.AllRightsReserved.CHEMLIST,CHEMCATS:Copyright?2009AmericanChemicalSociety.AllRightsReserved.TaskHistory2September2012SciFinderScholarPage:2Answer1:RNHOHEtNRRCO2HMeOH
7、R•HOR+2COHROAbsolutestereochemistry.HAbsolutestereochemistry.N1.1R:NH3,S:H2O,rtHEt1.2R:mCPBA,rtR1.3R:Disodiumcarbonate,S:H2ORR2.1S:CH2Cl2,rt;rt→-92°C2.2R:O(C(=O)CF3)2,-95--85°CRR2.3R:NaBH4,S:MeOH,-10-0°CMeONOAcSHOH2.4R:H2O3.1R:F3CCO2H,S:CH2Cl2,rt;rt→-8
8、0°CMeOOMe3.2R:Bromosuccinimide,-80--45°CAbsolutestereochemistry.3.3R:NaHCO3,S:H2ORotation(-).3.4R:AgBF4,S:THF,rt(Step2.1)2September2012SciFinderScholarPage:3NHEtR2RRRRRMeONOAcSHOHMeOOMeROMeORNEtSNR2HRRHAbsolutestereochemistry.NOTE:3)sea
