PCNA和Survivin在子宫内膜异位症中的表达和意义

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1、摘要目的：通过检测细胞增殖核抗原(Proliferatingcellnuclearantigen，PcNA)和凋亡抑制蛋白(Survivin)在子宫内膜异位症(简称内异症)中的表达，探讨子宫内膜异位症的发病机制。方法：采用免疫组织化学SABC法，检测了55例子宫内膜异位症患者的在位及异位子宫内膜中PCNA和Survivin的表达，并与30例正常子宫内膜组织进行比较。结果：l、PCNA在内异症组在位和异位内膜及对照组内膜的表达依次减弱，两两之间差异有显著性(PO．05)，且与月经周期无相关性(P>O．

2、05)；而在对照组增生期的表达强于分泌期(PO．05)。2、Survivin在内异症组异位和在位内膜及对照组内膜的表达依次减弱，两两之间差异有显著性(P0．05)，且与月经周期无相关性(P>O．05)；其在内异症组在位内膜增生期和分泌期的表达均强于同期对照组(P

3、

4、e：Todetecttheexpressionofproliferatingcellnuclearantigen(PCNA)andSurvivinmendometriosis，SOastoinvestigatethepathogenesisofendometriosis．Methods：ImmunohistochemicalStreptAvidinBiotinComplex(SABC)methodswasusedtoexaminetheexpressionofPCNAandSurvivinintheeutopicandectopicendometriumfrom55c

5、asesofendometriosis，andcomparewith30casesnormalendometrium．Results：TheexpressionofPCNAineutopicandectopicendometriumofendometriosisandinnonnalendometriumwastodecreasebyturns，andtherewassignificantdifferencebetweenanytwogroups．ThePCNAexpressionbetweenproliferativeandsecretoryphaseofeutop

6、icendometriumofendometriosishadnodifference，whichhadnocorrelationwithmenstrualcycle．ButincontrolgroupendometriumthelevelofPCNAduringproliferativephasewashigherthanthatduringsecretoryphase，whichhadanegativecorrelationwithmenstrualcycle．ThelevelofPCNAinsecretoryphaseofeutopicendometriumof

7、endometriosiswashigherthanthatinsecretoryphaseofcontrolgroup，buttherewasnodifferencebetweenproliferafivephaseoftwogroups．TheSun，ivinexpressioninectopicandeutopicendometriumofendometriosisandinnormalendometriumwastodecreasebyturns，andtherewassignificantdifferencebetweenanytwogro