黑豆洗方外用治疗手部湿疹的临床疗效观察及作用机理探讨

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1、山东中医药大学硕士学位论文黑豆洗方外用治疗手部湿疹的临床疗效观察及作用机理探讨姓名：王欣申请学位级别：硕士专业：中医外科学指导教师：杜锡贤2003.4.20提要擎SOll,f7手部湿疹是皮肤科临床的常见病、多发病，中药治疗该病疗效显著。本课题应用中医理论及现代技术从I临床和实验两方面观察了导师用于临床多年的经验方一一黑豆洗方外用治疗手部湿疹的临床疗效并对其作用机理-_●’。。●_t=-一进行了初步探讨。／I临床观察中，黑豆洗方外用治疗手部湿疹59例，治愈率＼32．2％、总有效率67．8％，与去炎松尿素软膏

2、组疗效相当，且在对各种临床I口／、。=7症状及自觉症状的改善方面及远期疗效明显优于后者。』j读验部分通过抗炎一／实验、抗过敏性接触性皮炎实验、止痒实验和对兔皮肤刺激实验说明该药外用具有抗Ⅳ型变态反应、止痒的作用，且对皮肤无刺激性。本研究认为黑豆洗方外用治疗手部湿疹疗效肯定，复发率低，其良好的润肤、止瘁、抗Ⅳ型变态反应作用为本病的治疗提供了部分临床及理论依据。关键词手部湿疹；中医药疗法；临床研究；箧垂夏臣认抄ClinicalAndExperimentalStudyOnHeidouLotionInTreati

3、ngHandEczemaSpeciality：Dermatology，SurgeryofTCMAuthor：WangXinTutor：Prof．DnXixianAbstractHandeczema(HE)isacommondermatologicdisease．TraditionfilchineseMedicine(TCM)hasbroadprospectsintreatingit．Basedonmytutor．professorDUXixian’Sabundantclinicalexperiencesa

4、ndthereferenceofancientandmodernbibliography，thedissertationisaimedtoselectaneffectiveexternallotion—Heidoulotionintreatinghandeczemaandtostudythetreatingmechanismofit．，TheprojectismadeupoftWOparts：theclinicalstudyandtheexperimentalstudy．Inclinicalstudy．9

5、3patientsofHEweredividedintotwogroupsatrandom：59CaSeSweretreatedwithHeidoulotionwhiletheother34casesweretreatedwithTriamcinoloneAcetonideAcetateUreaCream．Result：theHDlotiongroup’SclinicalcurerateiS32．2％andthetotaleffectiverateiS67．8％．whilethecontrolgroup’

6、SclinicaIcurerateiS20．59％andthetotaleffectiverateiS52．94％．Thesetwohavenonotabledifierencethroughstatisticalanalysis．AndthecurativeeffectoftheHDlotiongroupafter3monthsisbetterthanthatofthecontrolgroup．Inexperimentalstudy，throughexperimentsonanimalmodelsres

7、ultsshowthatHeidoulotionhaslittleanti．acurateinflammationeffectandnotableanti-IVhypersensitivityeffectwithlittleirritationtotheskin．’Throughallthesestudieswecanseethatwithgoodclinicaleffectanddefiniteanti-IVhypersensitivityeffect，HDlotionisaeconomicalexte

8、rnalTCMcompoundintreatingHE．Butwestillhavemuchworktodo．Forexample，wemustfurthertheexperimentalstudiesinordertoknowtheexacttreatingmechnismofHDlorion．Keywords：handeczema；externaltherapyofTCM；clinicalobservation；exper