FHIT在乳腺癌中的表达及其与临床病理指标之间的关系

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1、上海交通大学硕士学位论文FHIT在乳腺癌中的表达及其与临床病理指标之间的关系姓名：徐国萍申请学位级别：硕士专业：外科学（普外科）指导教师：何萍青20080501结论：FHIT表达降低可能对乳腺癌的演化和进展具有一定重要作用；与浸润性导管癌的淋巴结转移、临床分期密切相关；与Cerb-B2、p53表达相关，可为乳腺癌的早期诊断、进一步治疗及预后判断提供必要的理论依据。关键词乳腺癌，FHIT，Cerb-B2，p53，免疫组化EXPRESSIONCHARACTERISTICSOFFHITINBREASTCARCINOMASANDITSRELATIONSHIPWITHCLI

2、NICOPATHOLOGIALPARAMETERSABSTRACTObjective:TostudytheexpressionofFHITinbenignandmalignantbreastdiseaseanditsrelationshipwithclinicopathologicalparametersinbreastcarcinoma.Toapproachitsclinicalsignificanceofguidingthetreatmentandprognosisdirectionsofbreastcarcinoma.Methods:Theexpressio

3、nofFHITwasdetectedbyimmunohistochemistryin42infitratingductalcarcinomatissues,8intraductalcarcinomatissues,16atypicalhyperplasiaofductalepitheliumtissuesand30mastopathiatissues,andrunthepathologicobservationandsemiquantitativeanalysisofFHIT.Results:ThepositiveexpressionofFHITinmastopa

4、thiatissues,atypicalhyper-plasiaofductalepitheliumtissues,intraductalcarcinomatissues,infitratingductalcarcinomatissuesdeclinedbydegrees.Thereisstatisticaldifferencebetweenthem(P＜0.01).ThenegativeexpressionrateofFHITinbreastcarcinomatissueswithlymphnodemetastaseswassignificantlyhigher

5、thanthatwithnolymphnodemetastases(P＜0.05).ThepositiveexpressionrateofFHITwasfoundin90.0%(stageI)、43.7%(stageII)、12.5%(stageIII).Thereisstatisticaldifferencebetweenthem(P＜0.01).ThepresenceofFHITandCerb-B2arenegativecorrelationstatisticallyandrS=-0.357(P＜0.05).ThepresenceofFHITandP53are

6、positivecorrelationstatisticallyandrS=-0.360(P＜0.05).NostatisticallysignificantdifferencebetweenFHITandage,tumorsize,histologicalclass,ER,PRwasnotedininvasivecarcinoma(P＞0.05).Conclusions:TheseresultssuggestthatthereducedexpressionofFHITmayplayanimportantroleindevelopmentandprogressio

7、nofbreastcarcinoma.TheremaybeanassociationbetweenexpressionofFHITandlymphnodemetastases,TNMstage,highexpressionofCerb-B2andp53alteration.Itmayofferguidetoearlydiagnosis,furthertreatmentandprognosisdirections.KEYWORDS:breastcancer,FHIT,cerb-B2,p53,immunohistochemistry上海交通大学学位论文原创性声明本人郑

8、重声明：所