基于WEB服务的新药研发网格

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1、上海交通大学硕士学位论文基于Web服务的新药研发网格姓名：江茂军申请学位级别：硕士专业：计算机系统结构指导教师：马范援20070101摘要在将传统应用程序移植成Web服务时，参考了目前两种通用方法，指出侵入式方法更适合本文；采用了一些新的网格计算和Web服务方面的标准规范，比如作业提交描述语言JSDL，Web服务资源框架WSRF，探索将新技术规范引入网格系统的可行性。最后，本文分别在原有的非Web服务环境中和Web服务环境中进行了一组对比实验，测试引入Web服务之后新药研发网格的计算性能，分析影响性能的可能因素；

2、并对Web服务平台进行优化，测试优化之后Web服务平台的性能变化。关键字：网格计算，Web服务，虚拟筛选第II页ABSTRACTBuildDrugDiscoveryGridbasedonWebServicesABSTRACTNowadays,withthein-depthresearchofdistributedcomputingtechnology,GridComputingandWebServiceshavebeengreatlydeveloped.Theconceptionofgridcomputingha

3、schangedfromtraditionalhighperformancecomputingusingdiscretecomputingresourcestoconstructingaplatformforresourcessharingandcooperativeoperations.Thegridarchitecturehasalsoshiftedfromprotocol-orientedarchitecturetoservice-orientedone.Ontheotherside,WebServices

4、isaloosely-coupledsystemwithasetofservicestocommunicatewitheachother.Theconnectionofservicesisbasedonthewell-definedinterfacesandprotocols.TheseattributesofWebServicesandGridComputingprovideagoodopportunitytocombinethem.ThisdissertationisbasedonNational863Hig

5、hTechnologyProject-DrugDiscoveryGrid.ThedissertationintroducesWebServicesintogridarchitecture,designsDrugDiscoveryGrid(DDGrid)architecturebasedonWebServices,solvestheproblemsinscalabilityandconventioncompatibilityoforginalsystem,andenhancesapplicationintegrat

6、ionandresourcesharingofDDGrid.Themaincontributionsofthethesiscanbesummarizedasfollows:Thewholearchitecturehasbeendividedintofourlayersaccordingtothefeaturesofdrugdiscovery.TheFabricLayeriscomposedofcomputingresourcesanddataresourceswidelydistributedthroughout

7、theInternet;TheService-OrientedArchitectureLayerisfundamentaltothegridsystem,whichprovidesinterfacesforaccessingresourcesofthelowlayer;TheService-OrientedToolingLayeraimstopresentauser-friendlyviewfortheuser;TheApplicationLayerrevealsapplicationinterfaceforgr

8、idusers.Inthisthesis,twoapproachesarestudied,whichareaimedforrunninglegacycodeapplicationsasGridservices.Somecutting-edge第III页ABSTRACTstandardsinWebServicesandGridComputinghavealsobeenint