多通道压电石英晶体生物传感器测试系统的设计研究

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1、上海交通大学硕士学位论文多通道压电石英晶体生物传感器测试系统的设计研究姓名：赵仁吉申请学位级别：硕士专业：微电子学与固体电子学指导教师：惠春20070101上海交通大学硕士学位论文RESEARCHONMULTI-CHANNELDETECTINGSYSTEMBASEDONPIEZOELECTRICQUARTZCRYSTALBIOSENSORABSTRACTThepiezoelectricquartzcrystalbiosensoristhebulkacousticwavedevicebasedonquartzc

2、rystal,whichisverysensitivetothechangesaboutthemassonthewaferandthestatearoudthecrystal.Andalsoitcansensitivelydetectthelittlechangesinthemicroreactionsandcantranslatethemtotheoscillationfrequencieswhichcanbemeasured.Itprovidesaeasyandquickmethodforgettingt

3、hereal-timeinformationforthemicroreactionsystem,soitbecomeoneofthehotspotsinthebiosensorresearcharea.Withthedevelopmentofthepiezoelectricsensorarray,themeasurementwiththesinglefrequencycounterandmanualdaterecordistoodifficulttomeettheneedofprecisionandspeed

4、.Sothisthesissetupthepiezoelectricbiosensordetectingsystem,withthepiezoelectricsensorarray、thedifferentialoscillationTTLcircuitinliquid、thesoftwaremodulefortheanalyseofthebiomoleculeinliquidandthepersonalcomputer,whichisforthemonitoring、processingandstoring

5、ofthereal-timeoscillationfrequenciesofthesensorarray.Togetthesteadyoscillationfrequeciesofthepiezoelectricbiosensorinliquid,thekeypointiswhetherthecircuitcaneffectivelymakethequartzcrystaloscillateintheresonantfrequency.SothisthesisdesignsaTTLdifferentialos

6、cillationcircuit,whichiseasy-structure,easy-oscillationandsteadyoscillationstate.Andalsosinceitsdifferentialfrequencyisonlyabout80KHz,whichislowerthenthequartzcrystalintrinsicfrequency--9NHz,soit’sreducetheneedforthefrequencymeasurement.2上海交通大学硕士学位论文ByLabVI

7、EWsoftware,thedetectingsystemforthemicromoleculeinliquidisdeveloped,whichmeasuresthefrequencywiththeAdvantech’scountercard.Itcanbeusedforthe2×2piezoelectricsensorarrayforthereal-timeoscillationfrequencymonitoringandvisualizationandalsoitprovidetheeasy-usedi

8、nterfaceBasedonthemeasurementoftheNaClsolution,wegetthefollowingconclusion:themeasurementprecisionofthesystemisdownto1Hz,thedifferenceamongdifferentchannelsisabout±15Hz,therepeatabilityofthesinglepiezo