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1、DiarrheaDiseaseThefirstaffiliatedhospitalSUNYAT-SENuniversityProf.WangHuishen王慧深Majorcauseofchildren’s(﹤5y)deathindevelopingcountriesin2002ARIdiarrheaMalariameaslesAIDSDiseaseinperinatalstageothers18%25%23%4%5%10%15%WHO/UNICEF.ClinicalmanagementofacutediarrheaSources:Theworldheal
2、threport2003,WHO,Geneva.GeneralintroductionClassificationPredisposingfactorEtiologyPathogenesisClinicalmanifestationsClinicalfeaturesofseveralcommonenteritisPersistentdiarrheaDiagnosisDifferentialDiagnosisTreatmentContentGeneralintroductionConceptcommondiseaseinchildhoodfrequency
3、andcharactersofstoolAges6m~2y50%<1ySeasonsviralorigins—lateautumnandspringbeginningbacterialorigins—summernoninfectiousdiarrhea—everyseasonMultiplesourcesandfactorsGeneralintroductionClassificationPredisposingfactorEtiologyPathogenesisClinicalmanifestationsClinicalfeaturesofseve
4、ralcommonenteritisPersistentdiarrheaDiagnosisDifferentialDiagnosisTreatmentContentCausesCourseDegreeInfectiousdiarrhea:virus,bacterium,fungi,parasitesNoninfectiousdiarrhea:diet,weather,othersAcute:<2wpersistent:2w2mchronic:>2mMild:thetimesofstoolandcharacterchangeSevere:accompan
5、ydehydration,electrolytesabnormalityandgeneraltoxicitysymptomsClassificationGeneralintroductionClassificationPredisposingfactorEtiologyPathogenesisClinicalmanifestationsClinicalfeaturesofseveralcommonenteritisPersistentdiarrheaDiagnosisDifferentialDiagnosisTreatmentContentGastric
6、acidsecretion,secretionandactivityofenzyme,qualityandquantityofdietchangequickly.Watermetabolism,toleranceofhydropenia,easytobodyfluiddisorder.Nerves,endocrine,circulation,liverandrenalfunction:notmature,easytodigestivetractfunctiondisorder.Predisposingfactor-1Developmentofinfanc
7、ydigestivesystem:notmaturePredisposingfactor-2Defensesystem:notmatureThreedefensesystem():microflora,epithelium,immunityGrowanddevelop,demandfornutrients,burdenofthestomachandintestines,easytoindigestion.Artificalfeeding:enteritismorbility10timeshigherthanbreastfeeding.milk:nutri
8、tionalingredientdestroyedmilktool:disinf