noncodingrna非编码rna

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1、Repertor:XiaoningYuanOct.9.2012NoncodingRNAIrnne.MP,ChengG,Wieland.S,etal，2007NoncodingRNAIntroductionClassificationResearchmethodMechanismTherelationshipwithmajordisease1.IntroductionNoncodingRNA(ncRNA)isakindoftranscriptswithouttheabilityofcodingproteins,whichexistwidelyinhighl

2、yeukaryotic.TheamountofthencRNAtranscriptsisupto98％ofthewholegenome’stranscripts.ThedifferenceinmolecularstructureandexpressivepatternfromotherkindsofRNAendowsthemspecificbiologicalfunctions.AlthoughexactfunctionsofmostncRNAarenotwellknown.ithasbeendemonstratedthatncRNAwasassocia

3、tedwithsomehumandiseases．2.Classification18—30nt:miRNA，siRNA，piRNA30—200nt:rRNA，tRNA，snRNA，snoRNA，SLRNA，SRPRNAMorethan200nt:mRNA-likenoncodingRNAandsoon3.ResearchingmethodMethodforidentification:bioinformationestablishspecificcDNAlibrariesDNATilingchipIdentification3.Researchingm

4、ethodMethodforreserchingfunction:ClusteringmethedNockout4.Mechanisma.NoncodingRNAcaninteractwithDNA,forexample,noncodingRNAcanmodifychromosomeconfiguration,andthenaffecttranscriptionactivityoflocalregionofDNA.4.Mechanismb.NoncodingRNAcaninteractwithmRNAtoadjusttheedition,stabilit

5、yandthetranslationofmRNA.4.Mechanismc.NoncodingRNA,asaregulaterforsynergismcan,canbindtoproteinfactorandchangethebiologicalactivityoftheprotein.chemotaticnoncodingRNAalsorecruitproteintospecificsiteofacell.4.Mechanismd.NoncodingRNAwhichoverlapitselfandbeacomplexhigher-orderstruct

6、ure,prividespaceorbindingsiteformolecularandproteinfactor.besides,somebodyholdtheopinionthatRNAmolecularsimimulateprionproteinconversion.5.Therelationshipwithmajordiseasea.Neurologicaldisease:schizophrenosisautismmelancholiahyperactivityTherelationshipwithmajordiseaseb.cancerTheH

7、19noncodingRNAisessentialforhumantumorgrowthThesignalingpathwaymediatedbyncRNAassociatewithhunmantumorgrowthTherelationshipwithmajordiseasec.otherdiseasepsoriasissusceptibilityrelatetoPRINSRNAThankyou!