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1、Updatedandnewcommandsformeta-analysisinStata™MichaelJ.BradburnCancerResearchUKMedicalStatisticsGroup,CentreforStatisticsinMedicine,Oxford,UKThisdocumentandtheStataprogramsreferredtobuildonpreviousworkdoneincollaborationwithJonDeeksandDougAltmanfromtheCentreforStatist
2、icsinMedicine,Oxford.ThedialogboxinterfacewaswrittenbyTomSteichen.1IntroductionMeta-analysisisthestatisticalmethodologyusedtocombinedatafromtwoormorestudiesthathaveaddressedthesamequestion.SeveralmethodsforthistypeofanalysishavebeenimplementedintheStatasoftware,inclu
3、dingbasicanalysesofaggregatedata(metaandmetancommands),cumulativemeta-analysis(metacum),diagnostics(metainf,metabias,metatrim,galbr,funnel)andmeta-regression(metareg).AlloftheseprogramswereoriginallywrittenfortheStataTechnicalBulletin,andaredescribedindetailintheresp
4、ectivesubmissions.Chapter18ofEggeretal.(2001;availableonlineathttp://www.bmjpg.com/books/sysrev/chapter18.pdf)formsamorecompleteintroductiontometa-analysisinStata.Thistextdescribesonlyasubsetofthesemethods.Thearticlefallsintwoparts:toillustrateenhancementstothemetan,
5、funnelandlabbeprogramspreviouslysubmittedtotheStataTechnicalBulletinin1998(Bradburnetal.),andtointroduceanewcommand,metannt.Section2startsbyrecappingonwhattheexistingprogramsdobeforesummarisingthenewadditions,togetherwithexamplesthatdemonstratetheiruse,andwillalsoint
6、roducethenewdialogboxinterface.Insection3,thenewroutinewillbeintroducedanddemonstrated,andsomefinalremarksmadeinsection4.Afulllistofoptionsavailableforallfourtheprogramsisgivenintheappendix.2.Themetan,funnelandlabbecommands2.1Aggregatedatameta-analysis(metan)2.11Pres
7、entcapabilitiesTheoriginal1998versionofmetancombines2x2tablesormeandifferences,andpresentstheresultsgraphicallyinaForestplot.For2x2tables,metancombinesstudiesusingthefixed-effectmethodsofMantel-Haenszel(thedefault)orinverse-variance,andbytheDer-Simonian&Laird(randome
8、ffects)model.Inaddition,oddsratiosmaybepooledbytheYusuf-Peto(“One-step”)method.Forcontinuousoutcomes,metancancombineestimatesofdiff
