右美托咪定关节腔内注射对膝关节镜手术后镇痛效果的观察

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1、授予单位代码10089学号或申请号丨3160匆IMH泠(E科大交HebeiMedicalUniversity硕士学位论文在职科学学位右美托咪定关节腔内注射对膝关节镜手术后镇痛效果的观察学位申请人：白冰导师：李双成副教授专业：人体解剖与组织胚胎学二级学院：基础医学院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报

2、的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。研究生签名师签章二级学院领导盖章

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4、旧丨r年十月#曰河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写，文责自负。导师签章研究生签名：4^71年七月一日7?今目录中文摘要·············································································1英文摘要············

5、·································································2研究论文右美托咪定关节腔内注射对膝关节镜手术后镇痛效果的观察前言·············································································4材料与方法····································································5结果······································

6、·······································7附图·············································································8附表·············································································10讨论·············································································13结论······

7、·······································································15参考文献·······································································16综述关节镜在膝关节骨关节病治疗中的作用·····························19致谢···················································································31个人简

8、历·············································································32中文摘要右美托咪定关节腔内注射对膝关节镜手术后镇痛效果的观察摘要目的：观察膝关节镜手术后关节腔内注射右美托咪定的镇痛效果；通过观察右美托咪定在镇痛中的安全性、有效性、患者综合满意度及其他镇痛药物的用量，为关节内应用右美托咪定对关节镜手术术后镇痛的临床应用提供参考依据。方法：选择承德市中心医院骨二科2014年02月－2014年07月择期行膝关节镜手术患者60例。ASA分级为I~Ⅱ级，年龄45~65岁，麻醉方式为蛛网膜下

9、腔阻滞麻醉。随机均分为两组：D组：右美托咪定1ug/kg用生理盐水稀释至20ml；L组：罗哌卡因1.5mg/kg用生理盐水稀释至20ml，两组患者均于撤除关节镜时关节腔内注射镇痛药物。记录患者术后静息时和运动时VAS评分和术后Ramsay镇静评分，以及术毕至首次需要镇痛药时间和术后24h内地左辛用量。结果：两组患者一般情况的比较差异无统计学意义；术后1~24ｈ，两组患者静息时ＶＡＳ评分差异无显著性，术后12~24ｈ运动VAS评分L组低于D组，差异有统计学意义（P＜0.05）；首次使用镇痛药时间，D组（192.0±4