homer1a在小鼠脑缺血再灌注损伤中的作用及机制研究

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1、分类号R743.31第四军医大学UDC616.8TheFourthMilitaryMedicalUniversity密级公开硕士学位论文Homer1a在小鼠脑缺血再灌注损伤中的作用及机制研究冯乐霄培养类别全日制学位类型专业学位一级学科(专业类)临床医学二级学科(专业)外科学（神外）研究方向缺血性脑损伤指导教师费舟教授（主任医师）培养单位西京医院神经外科二O一五年五月第四军医大学硕士学位论文目录缩略语表·······································································

2、························1中文摘要·······························································································3ABSTRACT····························································································6前言·············································

3、·················································10文献回顾······························································································12正文······························································································24实验一Homer1a基因敲除小鼠的繁殖培育与基因

4、鉴定·································241材料·····························································································242实验方法·······················································································253结果·········································

5、····················································284讨论·····························································································29实验二Homer1a在小鼠局灶性缺血再灌注脑损伤中的保护作用及对星形胶质细胞活化影响···············································································

6、·············31一小鼠局灶性脑缺血再灌注损伤模型建立·············································311材料··························································································312实验方法···················································································323结果·····

7、·····················································································344讨论··························································································36二Homer1a在脑缺血再灌注损伤中的保护作用及对星形胶质细胞活化影响···371材料················································

8、··········································382实验方法········································