瑞舒伐他汀钙在健康人体的药动学及制剂生物等效性研究

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1、授予单位代码10089学号或申请号13362H妗(E科大耷HebeiMedicalUniversity硕士学位论文在职科学学位瑞舒伐他汀钙在健康人体的药动学及制剂生物等效性研究学位申请人：邸琨导师：侯艳宁教授专业：药理学二级学院：白求恩国际和平医院2015年3月河北医科大学学位论文使用授权扩知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。

2、否则，承担相应的法律责任。研究生签名：呀嘁导师签章：核枚隹難、院_裏？磁、身啤：参私為曰V2f河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：成^谈导师签章：<義名邮年5"月日目录中文摘要·······································································································1英文摘要········

3、·······························································································4研究论文瑞舒伐他汀钙在健康人体的药动学及制剂生物等效性研究前言·······································································································7材料与方法································································

4、···························7结果·······································································································14附图·······································································································16附表························································

5、···············································22讨论·······································································································43结论·······································································································45参考文献·································

6、······························································45综述瑞舒伐他汀临床研究进展································································47致谢···············································································································53个人简历······································

7、·································································54中文摘要瑞舒伐他汀钙在健康人体的药动学及制剂生物等效性研究摘要目的：瑞舒伐他汀(Rosuvastatin)是一种具有高度选择性的3-羟-3-甲戊二酰辅酶A(HMG-CoA)还原酶抑制剂。本课题旨在建立健康人血浆中瑞舒伐他汀钙的液相色谱-质谱(LC-MS/MS)测定方