LC-MS Applications in Drug Development (Mike S[1]. Lee).pdf

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1、LC/MSAPPLICATIONSINDRUGDEVELOPMENTWiley-InterscienceSeriesonMassSpectrometrySeriesEditorsDominicM.DesiderioDepartmentsofNeurologyandBiochemistryUniversityofTennesseeHealthScienceCenterNicoM.M.NibberingUniversityofAmsterdamTheaimoftheseriesistoprovidebookswrittenbyexpertsinthevariousdiscipline

2、sofmassspectrometry,includingbutnotlimitedtobasicandfundamentalresearch,instrumentandmethodologicaldevelopments,andappliedresearch.BooksintheSeriesMichaelKinter,ProteinSequencingandIdentificationUsingTandemMassSpectrometry0-471-32249-0MikeS.Lee,LC/MSApplicationsinDrugDevelopment0-471-40520-5Fo

3、rthcomingBooksintheSeriesChhabilDass,PrinciplesandPracticeofBiologicalMassSpectrometry0-471-33053-1LC/MSAPPLICATIONSINDRUGDEVELOPMENTMikeS.LeeAJOHNWILEY&SONS,INC.,PUBLICATIONThisbookisprintedonacid-freepaper.•Copyright©2002byJohnWiley&Sons,Inc.,NewYork.Allrightsreserved.Publishedsimultaneous

4、lyinCanada.Nopartofthispublicationmaybereproduced,storedinaretrievalsystemortransmittedinanyformorbyanymeans,electronic,mechanical,photocopying,recording,scanning,orotherwise,exceptaspermittedunderSections107or108ofthe1976UnitedStatesCopyrightAct,withouteitherthepriorwrittenpermissionofthePub

5、lisher,orauthorizationthroughpaymentoftheappropriateper-copyfeetotheCopyrightClearanceCenter,222RosewoodDrive,Danvers,MA01923,(978)750-8400,fax(978)750-4744.RequeststothePublisherforpermissionshouldbeaddressedtothePermissionsDepartment,JohnWiley&Sons,Inc.,605ThirdAvenue,NewYork,NY10158-0012,(

6、212)850-6011,fax(212)850-6008,E-Mail:PERMREQ@WILEY.COM.Fororderingandcutomerserviceinformationpleasecall1-800-CALL-WILEY.LibraryofCongressCataloging-in-PublicationData:LibraryofCongressCataloging-in-PublicationDataisavailable.0-471-40520-5PrintedintheUnitedStatesofAmerica.10987654321CONTENTSP

7、refaceixAcknowledgmentsxi1.Introduction1EmergingAnalyticalNeeds/1IntegrationofLC/MSintoDrugDevelopment/3PartnershipsandAcceptance/6Overview/102.DrugDevelopmentOverview11AnalysisPerspectives/11TheFourStagesofDrugDevelopment/12DrugDiscovery/14P