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1、Anal.Chem.2005,77,1330-1337High-ThroughputNanoliterSampleIntroductionMicrofluidicChip-BasedFlowInjectionAnalysisSystemwithGravity-DrivenFlowsWen-BinDu,QunFang,*Qiao-HongHe,andZhao-LunFangInstituteofMicroanalyticalSystems,ZhejiangUniversity,Hangzhou,ChinaInthiswork,asimple,robust
2、,andautomatedmicrofluidicmechanicalfabricationtoolswereusedforproducingIMCs,chip-basedFIAsystemwithgravity-drivenflowsandwhereasthemicroelectronicmechanicalsystem(MEMS),devel-liquid-corewaveguide(LCW)spectrometricdetectionwasopedtoanadvancedstageatthetime,wasconsideredasabasicde
3、veloped.Thehigh-throughputsampleintroductionplatformfortherealizationofíTAS.Thelattertechnicalapproachsystemwascomposedofacapillarysamplingprobeandfacilitatedintegrationofanalyticalfunctionalcomponentsthatanarrayofhorizontallypositionedmicrosamplevialswithallowedahigherdegreeofm
4、iniaturizationiníTASthanIMC.aslotfabricatedonthebottomofeachvial.FIsampleThisiswell-demonstratedinchip-basedmicrofluidicsystems,loadingandinjectionwereperformedbylinearlymovingcurrentlythemostfar-developedformofíTAS,wheresamplethearrayofvialsfilledalternatelywith50-íLsamplesandh
5、andlingistypicallyinthepicoliter-to-nanoliterrange.However,carrier,allowingtheprobeinlettoenterthesolutionsindespiteearliereffortsofproducingcompleteMEMS-basedíTAS,thevialsthroughtheslotssequentiallyandthesampleincludingmicrofabricatedpressure-drivenpumps,4maindevelop-andcarrier
6、solutiontobeintroducedintothechipdrivenmentsinthefieldhappenedusingchipswithmicrofabricatedbygravity.Theperformanceofthesystemwasdemon-reactionandseparationchannelsemployingelectrokineticdrivingstratedusingthecomplexationofo-phenanthrolinewithsystems.SincethepioneeringworksofHar
7、risonetal.,inchip-Fe(II)asamodelreaction.A20-mm-longTeflonAF2400basedcapillaryelectrophoresis(CE),5thisformofíTAShascapillary(50-ími.d.,375-ímo.d.)wasconnectedtotheachievedtremendousprogress.6WhiletheuseofelectrokineticchiptofunctionasaLCWdetectionflowcellwithacellmeansforsample
8、introductionandinjectioninchip-basedCEisvolumeo
