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1、M™ETHODSINMOLECULARBIOLOGYSeriesEditorJohnM.WalkerSchoolofLifeSciencesUniversityofHertfordshireHatfield,Hertfordshire,AL109AB,UKForothertitlespublishedinthisseries,gotowww.springer.com/series/7651iTransgenesisTechniquesPrinciplesandProtocolsThirdEdit
2、ionEditedbyElizabethJ.CartwrightCardiovascularMedicine,UniversityofManchester,Manchester,UKivEditorElizabethJ.CartwrightCardiovascularMedicineUniversityofManchesterManchesterUKISSN:1064-3745e-ISSN:1940-6029ISBN:978-1-60327-018-2e-ISBN:978-1-60327-019
3、-9DOI:10.1007/978-1-60327-019-9SpringerDordrechtHeidelbergLondonNewYorkLibraryofCongressControlNumber:2009929336©HumanaPress,apartofSpringerScience+BusinessMedia,LLC2009Allrightsreserved.Thisworkmaynotbetranslatedorcopiedinwholeorinpartwithoutthewrit
4、tenpermissionofthepublisher(HumanaPress,c/oSpringerScience+BusinessMedia,LLC,233SpringStreet,NewYork,NY10013,USA),exceptforbriefexcerptsinconnectionwithreviewsorscholarlyanalysis.Useinconnectionwithanyformofinformationstorageandretrieval,electronicad
5、aptation,computersoftware,orbysimilarordissimilarmethodologynowknownorhereafterdevelopedisforbidden.Theuseinthispublicationoftradenames,trademarks,servicemarks,andsimilarterms,eveniftheyarenotidentifiedassuch,isnottobetakenasanexpressionofopinionasto
6、whetherornottheyaresubjecttoproprietaryrights.Printedonacid-freepaperSpringerispartofSpringerScience+BusinessMedia(www.springer.com)vToDan,EdwardandWilliamwithlove.PrefaceOneofthemajorchallengescurrentlyfacingthescientificcommunityistounderstandthefu
7、nctionofthe20,000–25,000protein-codinggenesthatwererevealedwhenthehumangenomewasfullysequenced.Thisbookdetailsthetransgenictechniquesthatarecurrentlyusedtomodifythegenomeinordertoextendourunderstandingoftheinvivofunctionofthesegenes.Sincetheadventoft
8、ransgenictechnologies,themousehasbecomebyfarthemostpopularmodelinwhichtostudymammaliangenefunction.Thisisduetonotonlyitsgeneticsimilaritytohumansbutalsoitsphysiologicaland,toacertainextent,itsanatomicalsimilarities.Whilstalargeproportionofthisbookisd
