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1、NEUROVASCULARMEDICINEThispageintentionallyleftblankNeurovascularMedicinePursuingCellularLongevityforHealthyAgingKennethMaiese,MDDivisionofCellularandMolecularCerebralIschemiaDepartmentsofNeurologyandAnatomy&CellBiologyBarbaraAnnKarmanosCancerInstituteCenterforMolec
2、ularMedicineandGeneticsInstituteofEnvironmentalHealthSciencesWayneStateUniversitySchoolofMedicineDetroit,MI120093OxfordUniversityPress,Inc.,publishesworksthatfurtherOxfordUniversity’sobjectiveofexcellenceinresearch,scholarship,andeducation.OxfordNewYorkAucklandCape
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4、Copyright©2009byOxfordUniversityPress,Inc.PublishedbyOxfordUniversityPress,Inc.198MadisonAvenue,NewYork,NewYork10016www.oup.comOxfordisaregisteredtrademarkofOxfordUniversityPressAllrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,ortra
5、nsmitted,inanyformorbyanymeans,electronic,mechanical,photocopying,recording,orotherwise,withoutthepriorpermissionofOxfordUniversityPress.LibraryofCongressCataloging-in-PublicationDataNeurovascularmedicine:pursuingcellularlongevityforhealthyaging/[editedby]KennethMa
6、iese.p.;cm.Includesbibliographicalreferencesandindex.ISBN978-0-19-532669-71.Pathology,Cellular.2.Pathology,Molecular.3.Nervoussystem—Degeneration.4.Inflammation—Mediators.I.Maiese,Kenneth,1958-[DNLM:1.NervousSystemPhysiology.2.Aging—physiology.3.CellPhysiology.4.Ne
7、urodegenerativeDiseases—prevention&control.5.Neurons—physiology.WL102N51222008]RB113.N482008616.07—dc222008006253987654321PrintedinChinaonacid-freepaperPrefaceItisestimatedthatmorethan500millionindividualsgenerationofoxygenfreeradicalspeciesinexcessivesufferfromner
8、vousandvascularsystemdisordersinoruncontrolledamountsduringthereductionoftheworld.Thesedisorderscancomprisebothacuteoxygen.Theseoxygenfreeradical
