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1、阿片类镇痛药体外对精子运动影响的临床研究【摘要】目的：探讨阿片类镇痛药体外对精子运动的影响性，以期提高临床用药安全性，降低不良反应。方法：选取2010年7月到2013年1月40例精子活力精液标本，每份分为13份，1份为对照，分别在3种浓度下6种不同阿片类镇痛药在恒温箱孵育4h,运用计算机系统分析精子活力。结果：芬太尼、阿芬太尼、舒芬太尼、布托啡诺在1X10-5mg/mL>2X10-3mg/mL>0.05mg/mL浓度下其精子活力均较对照组低，两者比较差异均有统计学意义（P0.05）,而在2X10-3mg/mL>0.05mg/mL比较差异均有统计学意义（P0.05）,而在0.05mg/mL、0.
2、5mg/mL比较差异均有统计学意义（P0.05）,而在0.5mg/mL时比较差异有统计学意义（P0.05）,而它们与布托啡诺、地佐辛和阿芬太尼比较差异均有统计学意义（P【关键词】阿片类镇痛药；精子活力ClinicalstudyofopioidanalgesiceffectonthespermmotilityinvitroWANGZhifengl,LIUQingdel,YANYingl，YINGXiangrong2.1.DepartmentofAnaesthesia,ShaoxingSecondHospital,Shaoxing312000，Zhejiang,China；2.Department
3、ofUrology,ShaoxingPeople'sHospital,Shaoxing312000、Zhejiang,China[Abstract】Objectives：Toinvestigatetheopioidanalgesiceffectonspermmotilityinvitroinordertoimproveclinicaldrugsafetyandreducecomplications.Methods:40casesofsemensamplesfromJuly2010toJanuary2013weredividedinto3groups,with13samplesineachgro
4、up.Respectively,thethreegroupswereincubatedfor4hinthreeconcentrationsofsixdifferentopioidanalgesics・Computersystemsanalysisofspermmotilitywasdoneonthesamples.Results：Spermmotilityoffentanyl，alfentanil,sufentanil，butorphanolat1X10-5mg/mLand2X10-3mg/mL,0.05mg/mLconcentrationwaslowerthanthatincontrolgr
5、oup，withstatisticallysignificantdifference(P0.05)・Whileintheconcentrationof2X10-3mg/mL,0.05mg/mL,thedifferenceswerestatisticallysignificant(P0.05)・Intheconcentrationof0.05mg/mLand0.5mg/mL,thedifferenceswerestatisticallysignificant(P0.05)・Comparedwith0.5mg/mL,thedifferenceswerestatisticallysignifican
6、t(P0.05)・Conclusion：Thelowconcentrationofbutorphanolanddezocinehasnoeffectonspermmotility.Highconcentrationofbutorphanolanddezocinecancompletelyinhibitspermmotility.Lowconcentrationoffentanyl,alfentanilandsufentanilsignificantlysuppressspermmotility，andhighconcentrationsofpentazocinecanimprovespermm
7、otility・【Keywords］Opioidanalgesics；Spermmotility【中图分类号】R9【文献标志码】A阿片类镇痛药长期服用会产生耐药性和依赖性，对全身多器官、多系统均有明显损害。在临床上对阿片类镇痛药的研究多限于动物试验和长期接触毒品的吸毒者。目前研究证实，长期接触海洛因、吗啡等毒品男性患者的胎儿畸形发生率和中枢神经缺陷发生率明显高于正常人［1］。而就一些急性疼痛需服用
