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1、Publishedonline4May2011NucleicAcidsResearch,2011,Vol.39,No.13e87doi:10.1093/nar/gkr251NOA:anovelNetworkOntologyAnalysismethod11211JiguangWang,QiangHuang,Zhi-PingLiu,YongWang,Ling-YunWu,2,3,1,LuonanChen*andXiang-SunZhang*1KeyLaboratoryofManagement,DecisionandInformationSystems,Academyo
2、fMathematicsandSystems2Science,ChineseAcademyofSciences,Beijing100190,KeyLaboratoryofSystemsBiology,SIBS-NovoNordiskTranslationalResearchCentreforPreDiabetes,ShanghaiInstitutesforBiologicalSciences,Chinese3AcademyofSciences,Shanghai200233,ChinaandCollaborativeResearchCenterforInnovati
3、veMathematicalModelling,InstituteofIndustrialScience,UniversityofTokyo,Tokyo153-8505,JapanReceivedDecember13,2010;RevisedApril3,2011;AcceptedApril5,2011DownloadedfromABSTRACTknowledgeinspiritstheemergenceofGeneOntology(GO)projectwhichallowsannotatingtensofthousandsGeneontologyanalysis
4、hasbecomeapopularandofgenesinvariousspecies.Upto26October2010,thereimportanttoolinbioinformaticsstudy,andcurrenthavebeenmorethan2753338annotationsin48specieshttp://nar.oxfordjournals.org/ontologyanalysesaremainlyconductedinindivid-availableinGOdatabase(1),whichprovideconsiderableualge
5、neoragenelist.However,recentmolecularknowledgeforbiologiststounderstandthebehaviorofanetworkanalysisrevealsthatthesamelistofgenesspecificgeneorgeneproductinabiologicalsystem.withdifferentinteractionsmayperformdifferentThesegeneannotationsprovidedbyGOprojectfunctions.Therefore,itisneces
6、sarytoconsidermo-describethefunctionofasinglegeneorgeneproduct,lecularinteractionstocorrectlyandspecificallybutbiologistsaremoreinterestedintheGOenrichmentannotatebiologicalnetworks.Here,weproposeaanalysisofalargegenelistsincewidelyappliedhigh-throughputgenomic,proteomicandbioinformat
7、icsnovelNetworkOntologyAnalysis(NOA)methodtoatBeijingInstituteofGenomicsonOctober20,2012scanningtechnologies,suchasDNAmicroarrayandperformgeneontologyenrichmentanalysisonbio-proteinmassspectrometry,usuallyresultinasetofdif-logicalnetworks.Specifically,NOAfirstdefinesferentiallyexpress
8、edgen
