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1、第25卷第2期国外医学#生理、病理科学与临床分册Vo.l25No.22005年4月ForeignMedicalSciences#SectionofPathophysiologyandClinicalMedicineApr.2005mouscellcarcinoma[J].WorldJGastroenterol,2003,9(4):645-cells[J].ClinExpMetastasis,2004,21(2):149-157.649.21SmithermanAB,MohlerJL,MaygardenSJ,eta.lExpressionofan-17
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3、B,TiacciE,LisoA,eta.lSimplediagnosticassayforhairy1291-1299.cellleukaemiabyimmunocytochemicaldetectionofannexinA118ZhiH,ZhangJ,HuG,eta.lThederegulationofarachidonicacid(ANXA1)[J].Lancet,2004,363(9424):1869-1870.metabolism-relatedgenesinhumanesophagealsquamouscellcarc-i23SinhaP,
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5、nesophagealsquamouscellcarcinoma[J].ClinphysMethods,1998,37(3):105-116.CancerRes,2004,10(18Pt1):6013-6022.24WuYL,JiangXR,LillingtonDM,eta.lUpregulationoflipocortin20CicekM,SamantRS,KinterM,eta.lIdentificationofmetastasis-1inhibitstumournecrosisfactor-inducedapoptosisinhumanleuk
6、ae-associatedproteinsthroughproteinanalysisofmetastaticMDA-MB-miccells:apossiblemechanismofresistancetoimmunesurveillance435andmetastasis-suppressedBRMS1transfected-MDA-MB-435[J].BrJHaematol,2000,111(3):807-816.y胃癌蛋白质组学研究进展郑长黎综述文继舫审校(中南大学基础医学院病理学教研室,湖南长沙410078)摘要:使用二维凝胶电泳(2-DE)
7、、质谱和生物信息学技术,发现多种蛋白(如CagA,GroEL,TsaA等)与幽门螺杆菌的致胃癌机制有关;并找到了一些胃癌细胞株和胃癌组织的特异性蛋白,如ErbB3,annexinV,prohibitin等;证明了丙酮酸激酶M2蛋白等胃癌耐药相关蛋白的存在。关键词:胃癌;蛋白质组学;2-DE;质谱;幽门螺杆菌中图分类号:R735.2文献标识码:A文章编号:1001-1773(2005)02-0142-03胃癌是一种严重危害人类健康的疾病。蛋白质是分析细菌的蛋白构成,寻找免疫相关蛋白。菌株组学的兴起为胃癌的研究提供了理想的技术平台,26695和J99有1
8、,500个基因,已经完成基因测序。[3]对发现和鉴定胃癌相关生物标记、了解胃癌发生的Jungblut等用2-
