Springer.Bioinformatics.Computational.Cell.Biology.Springer

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1、iNotetoSpringer:thereisaÞgurethatgoeshere(commentedoutintheTex)thatIcan’tgettocompile.JoelEdwardKeizer1942-1999JoelKeizer’sthirtyyearsofscientiÞcworksetastandardforcollaborativeresearchintheoreticalchemistryandbiology.JoelKeizerservedtheUniversityofCaliforniaatDavisfaithfullyfor28years

2、,asaProfessorintheDepartmentsofChemistryandofNeurobiology,PhysiologyandBehavior,andasfounderandDirectoroftheInstituteforTheoreticalDynamics.Standingattheboundarybetweenexperimentandtheory,Joelbuiltnetworksofcollaborationsandfriendshipsthatcontinuetogrowandproduceresults.Thisbookevolved

3、fromatextbookthatJoelbeganbutwasnotabletoÞnish.ThegeneraloutlineandgoalsofthebookwerelaidoutbyJoel,onthebasisofhismanyyearsofteachingandresearchincomputationalcellbiology.ThoseofuswhohelpedtoÞnishtheproject—asauthorsandeditors—arehappytodedicateourlaborstothememoryofourfriendandcolleag

4、ue,JoelEdwardKeizer.AllroyaltiesfromthisbookaretobedirectedtotheJoelE.KeizerMemorialFundforcollaborativeinterdisciplinaryresearchinthelifesciences.ThisispageiiPrinter:OpaquethisPrefaceThistextisanintroductiontodynamicalmodelinginmolecularcellbiology.Itisnotmeantasacompleteoverviewofmod

5、elingorofparticularmodelsincellbiology.Rather,weuseselectedbiologicalexamplestomotivatetheconceptsandtechniquesusedincomputationalcellbiology.Thisisdonethroughaprogressionofincreasinglymorecomplexcellularfunctionsmodeledwithincreasinglycomplexmathematicalandcomputationaltechniques.Ther

6、eareotherexcellentsourcesformaterialonmathematicalcellbiology,andsothefocusheretrulyiscomputermodeling.Thisdoesnotmeanthattherearenomathematicaltechniquesintroduced,becausesomeofthemareabsolutelyvital,butitdoesmeanthatmuchofthemathematicsisexplainedinamoreintuitivefashion,whileweallowt

7、hecomputertodomostofthework.Noformerprogrammingexperienceisnecessary,thoughbasicprogrammingexperienceandfamiliaritywithcomputerswillbeveryhelpful.Thetargetaudienceforthistextismathematicallysophisticatedcellbiologyorneurosciencestudentsormathematicsstudentswhowishtolearnaboutmodeling