资源描述：
《胶原_肝素自组装多层膜修饰钛表面》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、中国组织工程研究与临床康复第14卷第51期2010–12–17出版JournalofClinicalRehabilitativeTissueEngineeringResearchDecember17,2010Vol.14,No.51胶原-肝素自组装多层膜修饰钛表面***★12222李全辉，徐祝军，李全利，沈军，张维波Surfacemodificationoftitaniumbycollagenandheparinself-assemblymultilayers12222LiQuan-hui,XuZhu-ju
2、n,LiQuan-li,ShenJun,ZhangWei-boAbstract1FirstDepartmentofBoneSurgery,BACKGROUND:ThebiologicalsurfacemodificationforthetitaniumandimprovingthebiocompatibilityoftitaniumsurfaceisoneYejishanHospitalofthehotspotsinresearchoftitaniumsurfacemodification.Affiliat
3、edtoWannanOBJECTIVE:Collagenandheparinmultilayerswerecoatedonpuretitaniumusingalayer-by-layerself-assemblytechnique,toMedicalCollege,Wuhu241001,achieveextracellularmatrixmodificationofthetitaniumsurfaceandtoimprovethecytocompatibilityoftitanium.AnhuiProvin
4、ce,2METHODS:Thefilmgrowthwasinitializedbydepositingonelayerofpositivelychargedpoly-L-lysineontheNaOH-treatedChina;Collegeoftitaniumsubstrate(porousandnegativelychargedsurface).Then,thefilmwasformedbythealternatedepositionofnegativelyStomatology,AnhuiMedica
5、lUniversity,chargedheparinandpositivelychargedchitosanviaelectrostaticinteractionsofpolyelectrolytes,andterminatedwithanHefei230032,outermostlayerofcollagen.Thechemicalcomposition,surfacetopographyaswellasroughnessofthemultilayerswereAnhuiProvince,Chinainv
6、estigatedbyusingdiffusereflection-fouriertransforminfraredspectroscopy,scanningelectronmicroscope,atomicforcemicroscope,andcontactanglemeasurementrespectively.WeculturedbonemarrowstromalcellsonthesurfaceofLiQuan-hui★,modified-titaniumandpuretitaniumrespect
7、ivelytoobserveitsadhesionandproliferation.Master,Attendingphysician,FirstRESULTSANDCONCLUSION:Theanalysisofdiffusereflection-fouriertransforminfraredspectroscopy,scanningelectronDepartmentofBonemicroscope,atomicforcemicroscope,andcontactanglemeasurementcon
8、firmedthat,heparin-collagenmultilayersformedSurgery,Yejishangraduallyonthetitaniumsurfaceandcouldimprovecelladhesion,proliferationanddifferentiation.Theheparin-collagenHospitalAffiliatedtoWannanMedicalmultila
