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1、FEATUREIspersonalizedmedicinefinallyarriving?MaloryeAllisonIt’snogoldrush,butdozensofplayersareemerginginpersonalizedmedicine,withbiotechs,bigandsmall,leadingtheway.Somebigpharmacompaniesandevenpayersremainskeptical,buteconomicsaside,therealwinnerswillbepatien
2、ts.helong-anticipatedfieldofpersonalizedThechallengescessesinpersonalizedmedicinemadeithardTmedicinefinallyappearstobegainingPersonalizedmedicine—‘therightdrugfortoconvincemanypeoplethatthestrategywasmomentum.Foryearsproponentshavebeentherightperson’—ismaturin
3、gthankstonewfeasible.pointingtothetargetedcancerdrugsGleevecdemandforbettervaluefrommedicines,theNogoodbusinessmodelsexistedeither.http://www.nature.com/naturebiotechnology(imatinibmesylate;Novartis,Basel)andhighcostofdrugfailures,theexplosioninBiotechs,suchas
4、Genset(Paris),andsmallerHerceptin(trastuzumab;Genentech/Roche,S.biomarkersandmaturinggenomicstools.startupslikeVariagenics(Framingham,MA,SanFrancisco,CA,USA/Basel)andpromising“We’vebeeninterestedinthisfieldfortenUSA)andGenaissance(NewHaven,CT,USA),atimewhenmos
5、tdrugs,likethesetwogleam-years,andhighlycommittedforfive,”saysMikewereinvariablygobbledupbeforehittinggold,ingexamples,wouldbeprescribedbasedonSamoszuk,chiefmedicalofficerforRocheoftenfortheircash(GensetbySerono(nowteststhatdetermineindividualbiologicaldif-Dia
6、gnostics(Indianapolis),oneofthebiggestMerckSerono,Geneva),VariagenicsbyHyseqferences.Patientswouldbematchedtothebestcompaniespioneeringthefield.“Untilafew(nowNuvelo,SanCarlos,CA,USA),anddrugfortheirgenotypeortheexactsubtypeofyearsago,thetechnologyjustwasn’trip
7、e.”GenaissancebyClinicalData(Newton,MA,theirdisease,anddoctorscouldavoidprescrib-ThefieldhasalsobeenheldbackbecauseUSA)).Thelowmarginsofthediagnosticsingdrugsthatmightcauseseriousharminthemostlargepharmaceuticalcompaniesjustbusinessmadeitextremelydifficultfort
8、hosewrongpatients.haven’tbeenveryinterested.Althoughpropo-companiestoleadthecharge.ThetrialsneededButHerceptinandGleevechavestoodalonenentsarguedthatpersonalizedmedicinewastoevalua
