基于静息态功能磁共振alff算法人脑老化的研究

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1、报的专利等知识产权均归河北医科大学所有。否则，承担相冀獠啾撇蜘9译二嚣?警憋营河北医科大学研究生学位论文独创性声明本沦文是在导师指导下进行的研究工作及取得的研究成果，除了文中特剐加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成采，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签稻：瑟编导师签章：r皤年月日目录中文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯l英文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯3英文缩写⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯

2、⋯⋯⋯⋯⋯⋯6研究论文基于静息态功能磁共振ALFF算法人脑老化的研究前言⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．7日lJ舌⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯。7材料与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯·．8结果⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯·10附图⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯12附表⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯·14讨论⋯⋯⋯⋯⋯

3、⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯·15结论⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯·22参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯··23综述BOLD在正常老化中的应用⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯27致谢⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯40个人简历⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯··41英文摘要—————————————————————————————————————————

4、———————————————一Amplitudeoflow—frequencyfluctuationstudyofrs．fMRIinthecomparationoftheyoungpeopleandtheelderlyABSTRACTObjective：Withtheapproachoftheagingsociety，brainagingattractsgreaterattentioninthefieldofmedicine．Manysubjectscarriedoutwideanddeepstudiesonb

5、rainaging．Withtheagegrowing，thecells，themorphology，andthefunctionofthebraintissueweredeclining．Thusthefunctionsofthebodywereaffected,suchascoordination，orientationability，memory．cognitiveabilityandthinking，etc．P。一●一●lhemainchangesinthemorphologyappearancesthi

6、nnedcoaex，narrowedgyrus，thickenedmeningeal，widenedsulci，enlargedventricle，etc．However，Inrecentyears，numbersofsrudieshaveshownthatthe丘mctionsoftheelderlynotonlyaffectedbystructurechanges，butalsoaffectedbybrainfunction．Inthisstudy，westudiedthedifferencesofthebr

7、ainactivitybetweentheyoungandtheelderlygroupintherestingstate，usingamplitudeoflow-frequencyfluctuation(ALFF)studyofresting．statefunctionalMRI(rs一恻)．Methods"Thesubjectsweredividedintotwogroups：theyounggroupincluding60participantes(23males，37females，rangefrom22

8、to3lyears．meanage：26．2±1．9years)；theelderlygroupincluding61participantes(23males，38females，rangefrom45to65years，meanage：52．6-t-5．9years)．Thevolunteershadnoassociatedtraumaandsymptomsofbra