用于药物传输的微阵列系统的设计与实现

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1、THEDESIGNANDIMPLEMENTATIONOFMICROARRAYSYSTEMSFORDRUGDELIVERYABSTRACTThemicroneedle，asanoVeldmgdeliVe巧nlelIhod，h弱beenwidelystudiedbyresearcherstheseyearsbecauseitisIninimallyinVasiVe，painles§，porta_bility，easytouseandhasgreatpotentialapplications．Currently，biodegradablemicroneedledeliVerydmgbym

2、ixingde伊adablepolymerwiththedmg，thedmgcontentofttlemicroneedlearelow．Thus，increasingthedmgcontentofbiodegrada_blemicroneedleisgreatsignificance．Basedonthestudya11dthetecllnologydeVelopmentofbiodegradableIIlicroneedle，thisp印erproposethehalfhollowde铲adableInicroneedlewrhichbe哪eenmesolidmicroneed

3、lea11dthehollownlicroneedle，insidethehalfhollow111icroneedlet11ereisaholesmlcture也atitcanstorcdrug，soitcanincreasethedmgcontent．Forthedesignofhalfhollowde铲adablemicroneedle，tllisp印erproposestwof．abricationnlethods，oneisf．abricatedbydualmolds，andtheotherisfabricatedbythesumceadso印tionofhole．Bya

4、nalysisthef．orceofmicroneedlewhenthemicroneedlepierCeintothes姑n，di任．erentstnlcturesofmicroneedlesaredesignedanddif．ferentpararmeterssuchaslen昏handslantanglearesinmlatedbythesimulationsoRware．Inordertoproductmassmicroneemea玎：拶m01d，thispaper咖dythechemicalIIl北京化工大学硕士学位论文etchingofsiliconmicroneedl

5、e，sosiliconlnicroneedlecanbeusedasmicroneedleamlymold．Forex锄ining也ehalfhollowdegradablemicroneedle，“sp印eruses佃旧testexperiments：theamplificationobseⅣationandthenuorescenceobsefvation．Bothmethodscanbeusedtof抽ricatehalfhollowbiode昏．adablemicroneedle，butthetwom删shaVesomedi幅鼬nces，也eintemalstnlcture

6、ofhalfhollowbiodegradablemicroneedleisr01ll醢alldtheoperationissiⅡ1plebythcsu而ceadso哦ionofhole，Whiletheint锄a1stmctureofhalfhollowbiodegradablemicroneedleissmoo也alld也estlccessra{tcislowbydjIlalⅡ1：0lds．Themethodproposedinthisp星IpereallnOtonlyeompl或ethefabricationofhalfhollowmicroneedle，butalsof．a

7、bricateh0110wmicroneedleby协msfIemngthestrucmreofhalfhollowmicroneedle．Inaddition，thisp印ertestmetransdemalef．fectofmicroneedlebytomography，meexperimentalresultshowthatthebiodegradablemicroneedlecallpenetrateintotheshnofmice，soitVeri矽that