帕金森病亚型的认知功能特征与静息态功能磁共振成像分析

《帕金森病亚型的认知功能特征与静息态功能磁共振成像分析》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、万方数据第三军医大学硕士学位论文regionalhomogeneityofrestingstatefmri(ReHo)brainfunctionactivitiesofsubtypeofPDwithMCIintherestingstate，toexplorethedifferencesofnerveactivitybetweenPDsubtypeofPDwithMCI，aswellastheapplicationvalueoflocalconsistencyanalysisintheresearc

2、hofPDsubtype，andprovideatheoreticalbasisforearlyinterventionofPDsubtypeofdiseaseprogressionanddelaytheoccurrenceofPDD．MaterialsandMethods1．ParticipantssubtypeofPD：27tremor-dominant(TD)patients，33posturalinstabilityandgaitdifficulty(PIGD)patients；subty

3、peofPD谢thMCIpatients：19TDwithMCIpatiems，23PIGDwithMCIpatients；25healthycontrol(HC)．Alltheparticipantsaleage-，sex—andeducaton—matched．2．Montrealcognitiveassessment(MoCA)andmini—mentalstateexamination(MMSE)wereadministeredtomeasurethecognition．Hamiltond

4、epressionratingscale，HAMDwasadministeredtomeasuretheseverityofdepression．PartIIandIIIoftheUnifiedParkinson’SDiseaseRatingScale(UPDRS)wereadministeredtomeasurethedailylivingabilityandmotorperformance．TheHoehnandYahrscalewereusedtoassessthediseasestagin

5、gofPD；TrailMakingTest·A(TMT--A)，15pointsClockDrawingTest(CDT)，Verbalfluencytest(VFT)，Rey’SAuditoryVerbalLearningTest(RAVLT)andClockcopyingtoassessallthecognitivedomainofsubtypeofPDwithMCI．3．MRIdataacquisition：MRIimageswereacquiredusinga3．0TSiemensTimT

6、riowhole-bodyMRIsystem(SiemensMedicalSolutions，Erlangen，Germany)．Brainmagneticresonanceimages(T1-andT2-weightedimages)wereinspectedbyanexperiencedneuroradiologist，andnogrossabnormalitieswerefoundinanyoftheparticipants．Thefunctionalimagingdatawerecolle

7、ctedtransverselybyusinganecho-planarimaging(EPI)sequence．Three-dimensionalT1一weightedanatomicalimageswerecollectedsagittallyusingthefollowingvolumetric3Dmagnetization—preparedrapidgradient—echo(MP-RAGE)sequenceeachsubject．4．Functionalimagepreprocessin

8、g：PreprocessingwasperformedusingtheSPM8．5．Statisticalanalysis：DemographiccharacteristicswereanalysedusingSPSS20．0．Threegroupsofsampleswereanalysedusingsinglefactoranalysisofvarianceorvariancewithnonparametrictestwhendatadoesnotconform南thenorma