不同程度母爱剥夺对成年大鼠学习记忆影响的实验分析

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1、万方数据英文捅要一——————————————————————————————————————————————一leamingandmemoryinratsandexploreitspossibleneuro。biologicalmechanisms．Methods：Theneonatalrats7daysafterbinhwererandomlydividedintonormalcontrolgroup(Con)，partialmaternalseparationgroup(PMS)andcompletematernalseparationgroup(CMS)．T

2、oobservetheeffectsofmaternalseparationontheleamingandmemoryofadultratsbyusingMorriswatermaze，toshowthedamageofneuronsinhippocampusCAlareabyNisslstaininganddetectmemalondialdehyde(MDA)andsuperoxidedismutase(SOD)inhippocampus．Results：TheescapelatentperiodofPMSratswaslongerthanthatinCongr

3、ouponthirdday(PO．05、)：TheescapelatentperiodofCMSratswaslongerthanthatinCongroup(P<0．05)，thetimesofcrossingplatformandtheswimmingtimeintheDlatformareawerereduced(P<0．05)comparedwithCongroupandP

4、MSgroup，thedamageofneuronsinCA1areawasaggravated，ComparedwithCongroup．MDAwasincreased(P

5、ybeoneoftheneurobiologicalmechanismsofthereductionoflearningandmemoryinratadulthood．Thedegreeofmatemalseparationisdeeper,thelearningandmemoryofadultratsdecreasedmore，whichmaybetheresultfromtheneurondamageofthehippocampusCA1areacausedbyexcessiveaccumulationofoxygenfreeradicalinratbrain．

6、Keywords：Earlymaternalseparation，rat，learningandmemory,hippocampus，MDA，SOD-——————————————————————————————————————————————————一4万方数据英文缩写ELSMSMDASODConPMSCMSfM对HPCearlylifestress早期生命应激症maternalseparation母爱剥夺malondialdehyde丙二醛superoxidedismutase超氧化物歧化酶controlgroup对照组partialmaternalseparat

7、iongroup部分母婴分离组completematernalseparationgroup完全母婴分离组FunctionalMRJ功能性磁共振成像研究Hippocampus海马5万方数据研究论文不同程度母爱剥夺对成年大鼠学习记忆影响的实验研究-▲上--J_刖吾研究表明人类生命早期应激(earlylifetimeevents，ELS)是成年后多种行为异常【1’3】及多种精神疾病的重要风险因素，可诱发严重抑郁症(ma]ordepression)、物质使用障碍(substanceusedisorder)、创伤后应激障碍(，posttraumaticstressdis