一种新型输尿管支架管的可溶解包被薄膜及生物相容性研究

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1、一种新型输尿管支架管的可溶解包被薄膜及生物相容性研究郑宗钊王瑨宋波李传贵张银甫黄赤兵[基金项目]第三军医大学校成果转化基金(2011XZH05,2012XZH04)[通信作者]黄赤兵，E-mail：huangchibing@medmail.com.cn(400037，重庆，第三军医大学新桥医院泌尿外科)[摘要]目的为一种带纳米铁牵引线输尿管支架管筛选出一种安全的可溶解包被材料并检测该材料及纳米铁线的生物相容性。方法通过对三种材料所形成薄膜溶解特性的比较选出所需材料。进一步研究所选材料溶液浓度及薄

2、膜厚度与溶解时间的关系。在SD大鼠背部进行该材料覆盖的纳米铁牵引线的肌肉植入试验，检测其生物相容性。结果初步确定用聚乙烯醇制备可溶解薄膜。聚乙烯醇薄膜溶解时间与溶液浓度无关（P＞0.05），与薄膜厚度呈正相关（P＜0.05），可利用薄膜厚度调节牵引线释放时间。生物相容性：术后1-2周，光镜下见所埋线周围有大量炎性细胞浸润；术后4周炎性细胞数量明显减少；术后12周牵引线周围仅见少量炎性细胞。结论聚乙烯醇能作为可溶解包被薄膜材料用于该新型输尿管支架管。聚乙烯醇及其覆盖的纳米铁牵引线具有良好的生物相容

3、性。[关键词]输尿管支架管；聚乙烯醇；生物相容性ExperimentalstudyofadissolvablefilmcoatedonanovelureteralstentandtheirbiocompatibilityZhengZongzhao,WangJin,SongBo,LiChuangui,HuangChibing(DepartmentofUrology,XinqiaoHospital,ThirdMilitaryMedicalUniversity,Chongqing400037,Chin

4、a)[Abstract]ObjectiveTofindasafeanddissolvablematerialwhichcanbeusedasadissolvablecoatedfilminanovelureteralstentwithnanoscaleirontractionandevaluatethebiocompatibilityofthismaterialandthenanoscaleirontraction.MethodsDeterminethetentativematerialacco

5、rdingtothecomparisonofthreefilmsmadeofthreedifferentmaterials.Dofurtherstudytoanalyzetherelationbetweenthematerial’ssolutionconcentrationandthefilm’sdissolvingtimeorthefilm’sthickness.Testthematerialandthenanoscaleirontraction’sbiocompatibilitybythem

6、uscleimplanttestinSDrats.ResultsThroughthecomparativeresearch,polyvinylalcoholwaschoseasthetentativematerial.Thepolyvinylalcoholfilm’sdissolvingtimewasrelatedtohigherlevelsofthefilm’sthickness(P<0.05),andwasnotassociatedwithsolutionconcentration(P>0.

7、05).Biocompatibility:Oneandtwoweeksaftertheimplantsurgery,therewereabundantcapillariesandinflammatorycellsaroundtheimplantedtraction.Afterfourweeks,inflammatorycellsweresignificantreduced,buttherewerestillabundantcapillariesandsomefibroblastscouldbes

8、eenaroundthecapillaries.Atthe12thweektherewereonlylittleinflammatorycells,thequantityofcapillariesandfibroblastshadnotmuchchangedcomparedwiththe8thweek.Thetractionandnanoscaleironalwayscouldbeseenclearlyineachperiod.ConclusionPolyvinylalcoholcouldbeu