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1、Nano-coatingprotectsbiofunctionalmaterialsThedemandtodevelopconvergenttechnologyplatforms,suchasbio-functionalizedmedicaldevices,israpidlyincreasing.However,thelossofbiologicalfunctionoftheeffectormoleculesduringsterilizationrepresentsasignificantandgeneralproblem.There
2、fore,wehavedevelopedandcharacterizedanano-coating(NC)formulationcapableofmaintainingthefunctionalityofproteinsonbiological-devicecombinationproducts.Asaproofofconcept,theNCpreservedthestructuralandfunctionalintegrityofanotherwisehighlyfragileantibodyimmobilizedonpolyure
3、thaneduringdeleterioussterilizingirradiation(≥25kGy).TheNCprocedureenablesstraight-forwardterminalsterilizationofbio-functionalizedmaterialswhilepreservingoptimalconditioningofthebioactivesurface.RupertTscheliessnig1,2,MartinZörnig3,EvaM.Herzig4,KatharinaLückerath3,Jens
4、Altrichter5,KristinaKemter5,AdnanaPaunel-Görgülü6,TimLögters6,JoachimWindolf6,SilviaPabisch7,JindrichCinatl8,HolgerF.Rabenau8,AloisJungbauer1,PeterMüller-Buschbaum4,MartinScholz5,6*andJoachimKoch3*1UniversityofNaturalResourcesandAppliedLifeSciences,Vienna,Austria;2Austr
5、ianCentreofIndustrialBiotechnology,Vienna,Austria;3Georg-SpeyerHaus,InstituteforBiomedicalResearch,FrankfurtamMain,Germany;4LehrstuhlfürFunktionelleMaterialien,TechnischeUniveristätMünchen,Garching,Germany;5LeukocareAG,München,Martinsried,Germany;6DepartmentofTraumatolo
6、gyandHandSurgery,Heinrich-HeineUniversity,Düsseldorf,Germany;7FacultyofPhysics,UniversityofVienna,Austria;8InstituteforMedicalVirology,JohannWolfgangGoethe-University,FrankfurtamMain,Germany*E-mail:joachim.koch@em.uni-frankfurt.de,martin.scholz@leukocare.comThemostcommo
7、nsterilizationproceduresforbio-functionalizedTherefore,newapproachestoavoidsterilization-mediateddamagemedicaldevices(e.g.,implants)forclinicaluse1-3are-irradiationofbio-functionalizedmaterialsareurgentlyneeded.Wehave(electronbeam),-irradiation,andethyleneoxide(EtO)gasd
8、evelopedanano-coating(NC)procedureforthestabilizationandsterilization.However,theseproceduresmightleadtohighen
