中医肾—脑—目系统指导弱视治疗作用及机理的研究

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1、EffectsandMechanismsofRenal-Brain-EyeSysteminTraditionalChineseMedicinetoGuaidtheTreatmentofAmblyopiaSpeciality:OphthalmologyofTraditionalChineseMedicineAuthor:ChenMeirongTutor:Prof.WangJingboAbstractObjective:Toexploretheessenceofrenal-brain-eyesystemintradi

2、tionalChinesemedicine,andtofinditsimportanceinpathogenesis,therapyprocessesofamblyopiafromthedocumental,animalexperimentalandtheoreticalaspects.Providingnewthoughtsandmethodsforclinicalresearchandtreatmentofamblyopia.Methods:1.moderndocumentalresearch:74artic

3、lespublishedformallyonliteraturematerialsfrom1984to2011weresearchedtakingtheamblyopiaaskeywords.TypesofsyndromesofamblyopiaandtheoccurrenceoftraditionalChinesemedicinewerecalculatedtoanalysisthepathogenesisofamblyopiaandregularityofmedicineapplication.2.exper

4、imentalresearch:UltrastructuralchangesofvisualcortexandNMDAR1geneexpressiontestedbyRT-PCRmethodsofamblyopiccatwereobservedbeforeandafterapplyingShiMingBaogranulethroughelectronmicroscopy.FunctionofShiMingBaogranuleonamblyopiaweretested.Treatmentprinciplesofto

5、nifingkidneyandliver,strengtheningspleenandqi,nourishingbloodontreatingamblyopiawerediscussed.3.Theessenceof"kidney-brain-eyesystem”intraditionalChinesemedicineanditsroleintheprocessoftreatingamblyopiawereexplored.Results:1.moderndocumentalresearch:Reinforcin

6、gdrugswerefoundmostcommonlyusedintreatingamblyopia.Medicineofnourishingyinandbloodwerefollowed.Liverandkidneydeficiency,spleenqideficiencywasthoughtasthemainpathogenesisofamblyopia.2.experimentalstudy:Strabismuscausedbyvisualimpairmentwerefoundbeingimprovedin

7、middledoseandhighdosegroupsthroughmorphologicalobservation.Theeffectsequencewerehighdosegroup,middledosegroup,lowdosegroup,salinegroupandmodelgroup.Differenceswerenotfoundbyhorizontalcomparisonbetweenvariouspartsofthedistrict.NMDAR1expressionin17thdistrictand

8、21adistrictonvisualcortexwerefounddecreasedinmodelgroup.NMDAR1expressionin17thdistrictinmiddleandhighdosegroupswerefoundincreasedcomparedwithmodelgroupaftertheapplicationShiMingBaogranule